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Showing 15 of 20167 papers

Signaling Through Girdin Underlies Excessive Cell Morphogenesis Resulting from Depletion of Neurodevelopmental Disorder-Related Neurexin-2.

Authors: Yako H, Takahashi M, Akiyama M, Suzuki A, Miyamoto Y, Yamauchi J

International journal of molecular sciences

Induced neurons (iNeurons) generated via the forced expression of Neurogenin-2 (NGN2) in human pluripotent stem cells (hPSC) represent a highly efficient and robust model system for studying human neu...

schizophrenia mental health open access

Molecular Dynamics and Electron Density Topology Reveal Ligand-Specific Interaction Patterns at the Dopamine D(2) Receptor.

Authors: Padilla-Bernal G, Herrera-Zúñiga LD, Vargas R

International journal of molecular sciences

Hepatic encephalopathy (HE) is a complex of pathological processes in the central nervous system leading to progressive neurological and mental illness in patients with severe liver disease or portosy...

schizophrenia mental health open access

Docking Analysis of Drugs Used in the Treatment of Alzheimer's Disease, Using Cell Membrane Receptors and Enzymes of the Kynurenine Pathway: A Pilot Study.

Authors: Badawy AAB, Dawood S, Clanchy FIL, Williams RO, Stone TW

International journal of molecular sciences

The epidermal growth factor receptor (EGFR, also known as ErbB1/HER1) is a transmembrane receptor tyrosine kinase of the ErbB family that regulates cell proliferation, survival, migration, and differe...

schizophrenia mental health open access

Redox Homeostasis, Metabolic Pathways and Plasticity in Uveal Melanoma Compared to Other Cancers.

Authors: Păsărică MA, Curcă PF, Dragosloveanu CDM, Nisipașu CI, Curcă GC

Cancers

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer, accounting for 15–20% of the disease [,,]. TNBC is characterized by the lack (or very low levels) of immunohistochemi...

schizophrenia mental health open access

D-Fructose Exposure Impairs Neuronal Development in Mouse Neural Stem Cells.

Authors: Hernandez JC, Baqueiro MDN, Bora L, Singh R, Torsoni MA, Torsoni AS, Ross MG, Desai M

International journal of molecular sciences

Pharmaceuticals, agrochemicals, and functional materials all contain sulfur-containing molecules, which are crucial to organic synthesis (; ). Organosulfur compounds constitute 20% of FDA-approved dru...

schizophrenia mental health open access

Nrf2 Deficiency Exacerbates Methamphetamine-Induced Neuronal Apoptosis and Cognitive Dysfunction in Male Mice.

Authors: Nie Q, Dong W, Zhang P, Yang G, Jing D, Hou Z, Peng Y, Yu Y, Li L, Hong S

International journal of molecular sciences

Intracerebral hemorrhage (ICH) is a serious neurological disease with high mortality, accounting for 10%–15% of all stroke subtypes (). This condition has a sudden onset and progresses rapidly, with u...

schizophrenia mental health open access

Developing a Phosphodiesterase 10A Inhibitor as a Novel Therapeutic Agent for Triple-Negative Breast Cancer.

Authors: Biswas M, Manirujjaman M, Zabaleta J, Wyczechowska D, Garai J, Yu Q, Del Valle L, Majumder S, Kayes T, Chen X, Keeton AB, Miele L, Maxuitenko YY, Li N, Piazza GA, Hossain F

Cells

Nurses have traditionally played an active role in providing patients with knowledge about health, disease, and self-care based on the assumption that patients lack sufficient knowledge and are unable...

schizophrenia mental health open access

Idiopathic pulmonary fibrosis and interleukins: a bibliometric analysis [1999-2025].

Authors: Xu J, Chen S, Liu L, Zhang J, Min Y, Zhou H

Journal of thoracic disease

Diabetes mellitus (DM) is a multifaceted metabolic disorder driven by genetic and environmental interactions [,]. With global prevalence rising steadily [,], projections estimate 578 million adults wi...

schizophrenia mental health open access

Epidermal growth factor receptor modulation for neural repair: Implications for neurodegenerative disease therapy.

Authors: Amin A, Badenes M

Frontiers in molecular neuroscience

Functional dyspepsia (FD) is a chronic gastrointestinal disorder characterized by symptoms such as postprandial fullness, early satiation, epigastric pain, or epigastric burning. According to the Rome...

schizophrenia mental health open access

Intracranial Candida parapsilosis infection occurring 2 years after burr-hole drainage for chronic subdural hematoma: a case report.

Authors: Li J, Lin S, Liu W, Li P, Luo L

British journal of biomedical science

Left ventricular assist device (LVAD) implantation is an established therapy in end-stage heart failure. Despite improved technologies and perioperative management, complications, including bleeding,...

schizophrenia mental health open access

An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease.

Authors: Wang J, Zhang Y, Sun S, Hu L, Yang D

Frontiers in pharmacology

According to the World Health Organization, schizophrenia is a chronic disorder that affects around 1% of the global population []. To manage and alleviate its symptoms, various antipsychotic drugs ha...

schizophrenia mental health open access

Transcriptome sequencing and validation of potential biomarkers associated with cognitive impairment after hypertensive intracerebral hemorrhage.

Authors: Tang Y, Yang B, Luo X

Frontiers in molecular biosciences

The Lipizzans are one of the oldest horse breeds in Europe and represent an important part of European cultural and equestrian heritage. Its history dates back to 1580, when Archduke Charles II establ...

schizophrenia mental health open access

The Evolution of Patient-Centered Nursing Care: From Passive Recipients to Active Partners in the Era of Generative AI.

Authors: Hisao FH

The journal of nursing research : JNR

Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by multi-domain cognitive deterioration spanning memory, executive function, language, and visuospatial abilities [,]. As t...

schizophrenia mental health open access

RP-HPLC quantification and separation of isomeric bacosides and exploration of their anti-schizophrenic potential by network pharmacology.

Authors: Swain HS, Ghosh B, Kulkarni OP, Rajesh V

RSC advances

The human gut microbiome, comprising trillions of microbial symbionts, is essential for maintaining systemic physiological homeostasis (). However, contrasting patterns underscore the plasticity of th...

schizophrenia mental health open access

LY86-AS1 predicts poor prognosis and inhibits progression in non-small cell lung cancer by targeting the miR-132-3p/RB1CC1 axis.

Authors: Liu Y, Pan J, Dai Y, Man S, Li J, Hong Y

World journal of surgical oncology

The brain relies on a careful balance between excitatory and inhibitory signals to function normally. When this balance is disrupted, for example because inhibitory synapses fail to form properly, thi...

schizophrenia mental health open access