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Showing 15 of 20167 papers

A transcriptional atlas of gyrification reveals dynamic spatio-temporal gene expression in the developing ferret cortex.

Authors: Barresi M, Johnstone A, Quezada S, Quigley A, Tolcos M

Brain structure & function

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the terminal follicular epithelium, with a worldwide prevalence of approximately 0.4%. It is characterized by inflammatory nodul...

schizophrenia mental health open access

Epigenetic changes associated with the progression of prion disease in Syrian hamsters (Mesocricetus auratus).

Authors: Frank LE, Flack N, Faulk C, Block AJ, Bartz JC, Larsen PA

Prion

Two-dimensional (2D) materials span a remarkable range of electronic properties, with graphene and hexagonal boron nitride (h-BN) representing the extremes of electrical conductivity and insulating be...

schizophrenia mental health open access

Impaired gephyrin G-domain trimerization and phase separation in a patient with developmental epileptic encephalopathy.

Authors: Bruckisch EHW, de Melo Aragão M, Dos Santos Rohde T, Huber AK, de Oliveira Torres M, Schwarz G, Liebsch F

EMBO molecular medicine

Over the past few decades, fluoroorganic chemistry has emerged as an essential component of modern drug discovery and agrochemical innovation, with fluorine incorporation enhancing chemical and metabo...

schizophrenia mental health open access

DNA methylation patterns re-establish during clonal expansion restoring cell-to-cell epialleles heterogeneity.

Authors: Costabile D, Russo M, Della Monica R, Buonaiuto M, De Riso G, Sabbarese M, Catapano G, Cocozza S, Visconti R, Chiariotti L, Cuomo M

Biology direct

IR induces injury in many tissues and organs. IR directly leads to abnormal cell function and metabolic disorders through its destructive effect on the molecular structure of cells. It also indirectly...

schizophrenia mental health open access

Genome-wide association and population-tailored polygenic risk for Parkinson's disease in Taiwan.

Authors: Chu YT, Su YA, Lin CH, Tai CH, Wu YR, Hong CT, Chen YW, Tsai MH, Hardy J, Mok KY, Wu RM, East Asian Parkinson Disease Genomics Consortium, Global Parkinson’s Genetics Program

NPJ Parkinson's disease

Uveal melanoma (UM) is the most commonly encountered primary intraocular cancer arising in adults [] and represents 3–5% of all reported melanomas []. The most common sites for development of UM are c...

schizophrenia mental health open access

Metabolic Therapy in Glioblastoma-Mapping the Evidence for Ketogenic Diet as an Adjunctive Strategy.

Authors: Wiśniewska D, Winiarska M, Krupa-Nurcek S

Nutrients

• The field of idiopathic pulmonary fibrosis (IPF) and interleukins (ILs) is attracting increasing attention. • The United States and China are leaders in this field and wield significant influence. •...

schizophrenia mental health open access

Plaque-Hepatic Targeting Nanotherapy Disrupts the PCSK9-LOX-1 Axis to Suppress oxLDL in Atherosclerosis.

Authors: Duan Y, Qiu Y, Zhu Y, Wang Q, Lin J, Duan Y, Wang Q, Dong Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Non-small cell lung cancer (NSCLC) accounts for roughly 85% of the total incidence of lung cancer []. Despite considerable advances in therapeutic strategies, which include targeted therapies and immu...

schizophrenia mental health open access

Gut microbial diversity and candidate keystone taxa in Indian tribes: Insights across lifestyle-ecological continuum and health associations.

Authors: Mollick SA, Khual GK, Ghosh A, Patel SK, Bhattacharyya S, Roy CS, Maile A, Nagarajaram HA, Longkumer M, Babu MN, Kundapur AR, Uniyal S, Chattterjee A, Mitra M, Sikdar M, Urade BP, Pulamaghatta VN

Current research in microbial sciences

Primary biliary cholangitis (PBC), previously termed primary biliary cirrhosis, is a chronic autoimmune disease that predominantly affects middle-aged women []. It is characterized histologically by c...

schizophrenia mental health open access

Machine learning-based lateralization and localization of seizure onset in focal cortical dysplasia patients using ictal scalp EEG.

Authors: Shin Y, Hwang S, Lee SB, Son H, Sunwoo JS, Lee SK, Park KI, Kim YG

Frontiers in neuroscience

Glioblastoma multiforme (GB) remains the most aggressive and fatal primary tumor of the central nervous system in adults []. It is characterized by rapid growth, high invasiveness and significant resi...

schizophrenia mental health open access

Transition-metal-catalyzed C-S bond formation: recent developments and pharmaceutical applications.

Authors: Muneer S, da Silva Brito N, Kanwal A, Tariq A, Rasool N, Brito JM, Santos RBC, Imran M, Saba S, Rafique J

Frontiers in chemistry

Despite being considered a stable epigenetic modification [–], increasing evidence suggests that DNA methylation establishment is more dynamic and heterogeneous than previously anticipated [–]. Assess...

schizophrenia mental health open access

Assessing variability in predictors of adequate follow-up after esophageal food bolus impaction: a retrospective study and literature review.

Authors: Darnell H, Bidarian S, Richter J, Ismail B

Translational gastroenterology and hepatology

Amphetamine-type stimulants, mainly including methamphetamine (MA), are the third most widely abused class of drugs globally, posing a significant global public health challenge []. As a synthetic sym...

schizophrenia mental health open access

Microcephaly, Agenesis of the Corpus Callosum, and Suspected Blake Pouch Cyst Presenting With Failure to Thrive in an Infant.

Authors: Ingram H, Knighton K, Skalka N, Chappell D

Cureus

Solvent interaction analysis (SIA) is an advanced proteomic technique that evaluates protein structures using aqueous two-phase systems (ATPSs). The SIA technique isolates different protein isoforms (...

schizophrenia mental health open access

Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma.

Authors: Nakhaei A, Taghavi A, Afshari AR, Davoudi F, Gheybi E, Jalili-Nik M

Cancer reports (Hoboken, N.J.)

Achalasia cardia (AC) or idiopathic megaesophagus is a rare primary esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter and the absence of coordinated p...

bipolar disorder mental health open access

Leveraging machine learning with real-world data for hypothesis generation by identifying exposomic predictors in Parkinson's disease among farmers.

Authors: Petit P, Berger F, Bonneterre V, Vuillerme N

Journal of Parkinson's disease

Spinal dural arteriovenous fistula (SDAVF) is the most common spinal vascular malformation account for approximately 70%–80% (), it is still rare, and the etiology of which is not entirely clear. Epid...

bipolar disorder mental health open access

Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety.

Authors: Hendriks M, Lokar M, Arnts H, Mestrom RM, Georgiev D, Vinke RS

Journal of Parkinson's disease

Two different systems of adaptation operate in the retina when the eye adapts for seeing in light and darkness, the photochemical adaptation and the neuronal adaptational one. The photochemical proces...

bipolar disorder mental health open access