📚 PsyDin Research Database

A segregating PTK2B variant in a primary biliary cholangitis (PBC) family induces PBC-like autoimmune features in knock-in mice.

Authors: Bian S, Yang Y, Chen Z, Wang L, Chen H, Liu S, He C, Li Y, Zhang X, Zhang F

Cell & bioscience

Focal cortical dysplasia (FCD) is one of the most common causes of medically refractory epilepsy (). Characterized by localized malformations in cortical development, FCD often necessitates surgical r...

Single-Stage Repair of Complex Congenital Aortic Arch Pathology With Dissection and Aneurysm in an Adult.

Authors: Ahmad N, Chen X, Huang Y, Li J, Wang Y, Zhang Q, Huang L

JACC. Case reports

Efficient membrane trafficking is critical for a variety of biological processes, performing key functions in all cell types. In neurons, membrane trafficking is particularly important given the long...

Assessing the Protective Effects of Pioglitazone on Radiation-Induced Cardiac Injury in an In Vivo Model: A Biochemical and Histopathological Investigation.

Authors: Amiri FT, Jalali-Zefrei F, Zamani E, Mohamed AH, Sourati A, Shourmij M, Majdayeen M, Salari A, Souri Z, Farzipour S

Current cardiology reviews

There is a rising trend of neurodevelopmental disabilities among children in the United States []. This is consistent with recent studies demonstrating a high prevalence of attention deficit/hyperacti...

Genetic dissection of the Drosophila BLOC-1 complex reveals distinctions in synaptic localization and homeostatic plasticity.

Authors: Stark R, Dehn C, Abadi N, Xiong Y, Porter L, Chen X, Dickman D

Molecular biology of the cell

Craniosynostosis is a condition characterized by premature fusion of one or more cranial sutures, resulting in abnormal skull growth and potential neurologic complications. The condition occurs in app...

Decoding Brain Development and Function Through GABAergic Inhibitory Neurons.

Authors: Batista-Brito R, Mayer C, Paredes M, Silva CG

The European journal of neuroscience

Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data.

Authors: Ferme T, Zorc M, Cotman M, Mesarič M, Dovč P

Animal genetics

The establishment of precise neural circuits in the developing central nervous system (CNS) depends on highly coordinated and dynamic morphological change and/or remodeling of neuronal cells [,,,]. Th...

pH-Responsive Carboxymethyl Cellulose-Encapsulating Hesperidin-Selenium Nanoparticles Attenuate Paracetamol-Induced Acute Kidney Injury via Keap-1/Nrf2, NF-κB, and Mitochondrial Apoptosis Modulation.

Authors: Gadelmawla MHA, Alam-Eldein KM, Saleh A, Adel S, Ali H, Ayman S, Tarek E, Mahran NA, Ashour AM, Alorfi NM, Alshehri FS, El-Sayed WN, Faraag AHI, Khames A, Selim SM

International journal of molecular sciences

Oligodendrocytes (OLs) are glial cells in the central nervous system (CNS) that produce myelin, a lipid-rich membrane that wraps around axons to provide metabolic and trophic support and increase acti...

Special Issue "Machine Learning Applications in Bioinformatics and Biomedicine: 3rd Edition".

Authors: Lyu H

International journal of molecular sciences

Chronic subdural hematoma is a common condition affecting patients undergoing neurosurgery and is particularly prevalent among older adults. Burr-hole drainage has become the preferred treatment for C...

EEG Microstate Alterations in Eyes-Open and Eyes-Closed Resting States Across the Alzheimer's Disease Continuum.

Authors: Simfukwe C, An SSA, Youn YC

Journal of clinical medicine

One of the most used analgesics and antipyretics, paracetamol (acetaminophen) has been linked with serious adverse effects, especially when used in high doses []. Although usually safe under recommend...

Systemic Ammonia Toxicity: An Underestimated Driver of Cerebral Energy Crisis in Hepatic Encephalopathy.

Authors: Tikhonova L, Maevsky E, Montoliu C, Kosenko E

International journal of molecular sciences

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder, and its prevalence is increasing markedly with population ageing. Although the diagnosis is based on a recogn...

Morphometric Inverse Divergence Networks Combined with HYDRA Identify Parkinson's Disease Subtypes with Distinct Transcriptomic and Serum Biomarker Profiles.

Authors: Bianco MG, Calomino C, Bonacci MC, Caligiuri ME, Cristiani CM, Scaramuzzino L, Buonocore J, Arcuri PP, Quattrone A, Quattrone A

International journal of molecular sciences

Cognitive impairment is a key feature of Alzheimer’s disease (AlzD) and related dementias [,]. The role of acetylcholine in memory has led to the development of therapeutic agents that inhibit its deg...

Special Issue "Molecular Application of Mass Spectrometry and Chromatography in Biomedicine".

Authors: Ventura G, Bianco M

International journal of molecular sciences

Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide. It is characterized clinically by tremor, rigidity, bradykinesia, and postural instability, and neuropathologic...

Grape-Derived Exosome-like Nanoparticles Ameliorate Prediabetes in Mice via Amino Acid Metabolic Reprogramming.

Authors: Liu Z, Cai S, Qiayimaerdan A, Tang Y, Su J, Yang Z

International journal of molecular sciences

In June 2023, aiming to more accurately reflect the underlying lipid metabolic issues, the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of th...

Solvent Interaction Analysis: A New Lens for Protein Structure and Diagnostics.

Authors: Zaslavsky BY, Stovsky M, Uversky VN

International journal of molecular sciences

Oligodendrocytes (OLs) are specialized glial cells in the central nervous system (CNS) responsible for forming the myelin sheath that wraps around neuronal axons. Myelin is crucial for the efficient t...

Blood Metabolomic Profiling of Systemic Responses to Dried Black Lychee in a Scopolamine-Induced Cognitive Impairment in Rats.

Authors: Weerateerangkul P, Kangwan N, Jeefoo WP, Kobroob A, Konguthaithip G, Intui K, Watcharakhom S, Kulprachakarn K, Chaipoot S, Parklak W, Chuljerm H, Samoechai S, Piengjaikum N, Namdech S, Laoung-On J, Jaikang C

Biology

The sophisticated computations underlying brain function arise from highly interconnected and dynamically regulated microcircuits consisting of two fundamental neuronal classes: (1) glutamatergic proj...