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Showing 15 of 20167 papers

Angiotensin II Receptor Signaling in the Hypothalamic-Pituitary-Adrenal Axis and Spleen After Spinal Cord Injury Depends on the Sympathetic Innervation Integrity.

Authors: Kellerova E, Snopkova J, Hvozdikova E, Pavel J

Cellular and molecular neurobiology

Traumatic brain injury (TBI) is a leading cause of long‐term neurological disability and remains a serious public health concern worldwide [, ]. Beyond the immediate mechanical injury, TBI also trigge...

PTSD treatment mental health open access

Safety and effectiveness of a modified technique for three-piece inflatable penile prosthesis implantation under local anesthesia with a minimal scrotal incision (Wang's incision) in the treatment of

Authors: Ni HS, Wang ZN, Ling XY, Chen G, Wang J

Translational andrology and urology

After the shoulder, the elbow joint is the second most dislocated joint. A common cause is axial overloading of the forearm, for example, due to a fall, which can damage the stabilizing ligamentous ap...

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Oyster hydrolysate attenuates osteoarthritis progression by modulating inflammatory signaling and extracellular matrix homeostasis.

Authors: Ji SY, Hwangbo H, Kim MY, Kim DH, Hong SH, Shim JH, Moon SK, Kim GY, Cho S, Choi YH

Nutrition research and practice

Neurodegenerative conditions affect millions of people worldwide and represent an important and growing cause of functional decline, long-term disability, and mortality []. Three leading causes of neu...

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Development of a Diagnostic Tool for Elbow Instability Combining 4D-CT Imaging and Mechanical Load Analysis.

Authors: Gehring J, Forster F, Meindl M, Maerz M, Simon M, Renner N, Uder M, Pogarell T, Braeuer L, Perl M, Mangold L

Biomedical engineering and computational biology

Globally, breast cancer remains the leading malignancy among women, with a substantial burden in both high‑ and low‑resource settings []. Although incidence rates are higher in wealthy nations, mortal...

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A Comprehensive Reactive-Oxygen-Species-Scavenging Metal-Organic Framework Orchestrates the AMPK-DOT1L-H3K79me3 Cascade to Alleviate Osteoarthritis.

Authors: Jin Y, Zhu C, Li T, Li R, Liu C, Li Y, Fang B, Xia L

Biomaterials research

Tuberculosis (TB) is one of the oldest known diseases, affecting humans since prehistoric times, as evidenced by characteristic lesions found in Neolithic skeletal remains [, ]. Spinal tuberculosis, s...

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Explainable machine learning for predicting lower extremity deep vein thrombosis in traumatic brain injury patients: development of a SHAP-guided Random Forest model.

Authors: Wang X, Liu X, Yu Z, Liu K, Xing Z, Hou M, Wang Z

Frontiers in neurology

The accelerated global population aging represents the most prominent demographic shift of the 21st century, posing substantial challenges to public health systems worldwide and socio-economic develop...

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DNA methylation changes following rapid maxillary expansion in children.

Authors: Ishiyama T, Takahashi M, Kamura H, Kawai T, Tajima A, Yamaguchi T

Scientific reports

Osteoarthritis (OA) is the most prevalent musculoskeletal disease, affecting over 7% of the global population and ranking among the leading causes of disability worldwide []. The convergence of obesit...

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Rapid resolution of variants of uncertain significance (VUS). A complementary role for zebrafish in the era of multi-million-dollar therapies.

Authors: Giacomotto J

NPJ genomic medicine

Migraine is a common and disabling neurological disorder characterized by recurrent attacks of moderate to severe headache accompanied by neurological and systemic symptoms []. It ranks among the lead...

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The inflammatory/fibrotic axis across organs: myelofibrosis as a model of reversibility.

Authors: Greven L, Fuchs SN, Gleitz HF, Schneider RK

JCI insight

Current therapeutic interventions for spinal cord injury (SCI) demonstrate limited efficacy. This condition induces severe and permanent physical, neurological, and psychological impairments, substant...

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Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.

Authors: Katsoula G, Arruda AL, Tutino M, Reimann E, Bittner N, Kreitmaier P, Shah KM, Swift D, Southam L, Suutre S, Silva GLV, Tootsi K, Märtson A, Mägi R, Mark Wilkinson J, Zeggini E

Nature communications

Damage to the testicles that affects sperm production is a major cause of male infertility. It can happen for several reasons, such as chemotherapy, toxins in the environment, infections, ischemia–rep...

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Tibial bone transport using external fixation in adults: a systematic review.

Authors: Giuli C, Di Pietro G, Farine F, Bocchi MB, Vitiello R, Palmacci O

Archives of orthopaedic and trauma surgery

Osteoarthritis, the most prevalent form of arthritis, is a chronic degenerative complex disease that is projected to affect over one billion individuals worldwide by 2050. Osteoarthritis is characteri...

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The Effect of Physical, Biochemical, and Electrical Culture Conditions on Articular Chondrocytes Used for Cartilage Tissue Engineering: A Narrative Review.

Authors: Turner ML, Fattouh AS, Whitaker IS

International journal of molecular sciences

The function of adrenal gland is regulated by a tightly controlled neuroendocrine system involving the hypothalamic-pituitary-adrenal (HPA) axis and the renin-angiotensin-aldosterone system (RAAS), ne...

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Comparative Protective Effects of Anakinra and Tocilizumab in Experimental Ocular Ischemic Syndrome.

Authors: Karimov S, Sezgin ET, Mammadov R, Suleyman B, Yaqudov K, Yazici GN, Coban TA, Suleyman H, Bayrakceken K

International journal of molecular sciences

• Our modified technique for three-piece inflatable penile prosthesis implantation (PPI) under local anesthesia via Wang’s incision (1.5–2.5 cm) was safe and feasible. All 102 patients completed surge...

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Terpenoids as Emerging Senotherapeutics: Mechanistic Insights and Therapeutic Potential.

Authors: Yi S, Park JY, Lee SJ

International journal of molecular sciences

Traumatic brain injury (TBI) is a devastating neurological disease caused by external mechanical forces, leading to structural damage or functional impairment of the brain. It is one of the leading ca...

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Spontaneous Coronary Artery Dissection and Takotsubo Syndrome: Converging Mechanisms, Diagnostic Pitfalls, and a Unified Clinical Algorithm.

Authors: Golino M, Shakfeh K, Stiglich AA, Font C, Rollini F, Mahowald MK, Velarde G, Adedinsewo D, Franchi F, Zgheib A, El Khoury G, Rivas Rios J, Mollo P, Abbate A, Celeski M, Marchetta M

Journal of clinical medicine

Androgenetic alopecia (AGA), as the leading cause of non‐cicatricial alopecia, has contributed to an increasing disease burden worldwide in recent years []. The global prevalence among men is approxim...

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