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Showing 15 of 20167 papers

Mitochondrial unfolded protein response as a central stress-integration hub: mechanisms and implications in disease contexts.

Authors: Xin Y, He Y, Liu X

Burns & trauma

Maintaining integrity of the plasma membrane requires robust resealing and repair. Cell types that repeatedly face mechanical stress, like skeletal muscle fibers, cardiomyocytes, and epithelial cells,...

PTSD treatment mental health open access

"CARING in Action": A Knowledge Mobilization Project on Co-Creating Evidence-Based Communication Training in Chronic Pain Care for Healthcare Professionals.

Authors: Taccardi D, Espinoza-Suarez NR, Shah S, Daly-Cyr J, LeBlanc A, Ghasemlou N, Cooper L, Bosma R, Roy R

Canadian journal of pain = Revue canadienne de la douleur

PTSD treatment mental health open access

Stress management by benzodiazepines in septic shock and critical illness: mechanistic and clinical evidence supporting alternative sedative strategies.

Authors: Lambertucci F, Skurnik D, Roux D, Arbibe L, Bezu L, Martins I, Kroemer G

Cell stress

Osteoarthritis (OA) is the most common degenerative joint disorder that is a major cause of disability in elderly individuals worldwide. Clinically, it is diagnosed based on a combination of character...

PTSD treatment mental health open access

New therapeutic target for osteoarthritis: modulating immune-metabolic aberrations and micromilieu remodeling in underlying bone.

Authors: Gao Y, Shen L, Su X, Yang M, Man K, Sun Y

Frontiers in pharmacology

Severe forms of Guillain-Barré syndrome (GBS) may lead to acute respiratory failure and a need for intubation and mechanical ventilation [, , , ]. While respiratory failure is due primarily to respira...

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Breast Cancer Risk Factors Analysis in Middle-Aged Women: Evidence From a Cross-Sectional Epidemiological Study.

Authors: Ansari H, Yadollahi S, Allahyari S, Hajigholami A

Health science reports

Articular cartilage, lining the ends of opposing bones within synovial joints, is a connective tissue characterized by thinness, smoothness, and viscoelastic properties. This tissue features a high ex...

PTSD treatment mental health open access

TGF-β2 drives lipid droplet accumulation in chondrocytes through the TβRI/p-smad3/fabp5 axis.

Authors: Wei J, Pi C, Qi Y, Yang W, Sun J, Xu X, Xie J

The Journal of biological chemistry

Recurrent spontaneous abortion (RSA) refers to ≥2 consecutive pregnancy losses with the same sexual partner before 28 weeks of gestation, including adverse outcomes such as spontaneous abortion, embry...

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Machine learning versus clinical scoring systems for predicting poor wound healing after posterior surgery for thoracolumbar tuberculosis.

Authors: Xiong T, Huo S, Zhang Y, Qin W, Fang M, Zhu Y

Journal of orthopaedic surgery and research

Spinal cord injury (SCI) is one of the most complex medical conditions and remains a major social and economic burden worldwide []. The main causes of SCI are traffic accidents, falls from heights, an...

PTSD treatment mental health open access

Hyperbaric oxygen therapy: a novel treatment option in complex regional pain syndrome and other chronic pain conditions.

Authors: Hájek M, Chmelař D, Poláčková A, Hodrová M, Dokulil M, Tlapák J, Jor O

Medical gas research

Fibrosis is characterized by persistent fibroblast activation, resulting in excess extracellular matrix (ECM) deposition, and is the common endpoint of chronic injury across organs. Fibrosis accounts...

PTSD treatment mental health open access

Arachidonic acid metabolism in spinal cord injury.

Authors: Yao X, Liu X, Cai W, Ning G, Zhang X, Zhou K, Feng S

Journal of advanced research

A wide spectrum of conditions, including neuropathic pain, complex regional pain syndrome (CRPS), migraines, and fibromyalgia, are well-recognized contributors to chronic pain. CRPS is a chronic pain...

PTSD treatment mental health open access

Impact of Running on the Risk and Progression of Knee Osteoarthritis: A Review of Current Evidence.

Authors: Glinski M, Kacprzak U, Dolega-Mostowska D, Adamaszek N, Stochaj L, Sochowska J, Buczkowska A, Danieluk J, Flejszman M, Wójcik J

Cureus

Experiencing emotional pain is fundamentally adaptive and serves a crucial evolutionary function: it signals social loss, separation from attachment figures, or threats to social bonds, thereby motiva...

PTSD treatment mental health open access

Targeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study.

Authors: Gao H, Chen Y, Liao P, Chai H, Zhong L, Cui Y, Li H, Zhang Z

PeerJ

Cellular senescence refers to persistent and irreversible cell cycle arrest triggered by diverse forms of cellular stress, accompanied by macromolecular damage, secretory features, and altered metabol...

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Adipose-Joint Crosstalk in Obesity-Induced Osteoarthritis: Mechanisms, Biomarkers, and Translational Therapeutic Opportunities.

Authors: Hang W, Triantafilou K, Zhou Y

Current rheumatology reports

Alzheimer’s disease (AD) is the most common form of dementia, which is a loss of memory and cognitive function and a change in mood or personality []. It targets primarily the hippocampus, amygdala an...

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Delta-opioid receptor-mediated neural protection and regeneration.

Authors: Li J, Xu Y, Chao Z, Khiati L, Xia Y

Neural regeneration research

Ischemic stroke (IS) ranks as the second leading cause of death and a primary cause of long-term disability worldwide, characterized by its high incidence, recurrence, and morbidity rates (). IS is pr...

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TDP-43-immunity-microbiota axis in amyotrophic lateral sclerosis: A potential pathogenic mechanism.

Authors: Abbassi Y, Fink D, Cei F, Niccolai E, Amedei A

Neural regeneration research

Osteoarthritis (OA) is a leading cause of pain and disability worldwide, with the hip and knee being the most commonly affected major joints. These forms of OA lead to individual suffering, reduced qu...

PTSD treatment mental health open access

Ferroptosis and aging: Inducing and catalyzing neurodegenerative diseases.

Authors: Song Q, Sun S, Song Y, Wang Y, Yuan Y, Zhang L, Cui Q

Neural regeneration research

Coronavirus disease 2019 (COVID-19), caused by the betacoronavirus SARS-CoV-2, is characterized by a range of clinical severities even among individuals with similar demographics [,]. Accordingly, SAR...

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