Comparative Protective Effects of Anakinra and Tocilizumab in Experimental Ocular Ischemic Syndrome.

• Our modified technique for three-piece inflatable penile prosthesis implantation (PPI) under local anesthesia via Wang’s incision (1.5–2.5 cm) was safe and feasible. All 102 patients completed surgery without conversion to general or spinal anesthesia, and reported tolerable pain (highest Numeric Rating Scale score: 4.51±1.72). • Conventional three-piece PPI typically requires general or spinal anesthesia and a 4–5 cm incision, limiting its use in elderly patients or those with comorbidities. Local anesthesia has been used for two-piece PPI; however, its use in three-piece PPI remains underreported. • Our modified technique uses staged multi-site nerve blocks, single stay sutures on each side for corporotomy closure, and selective drain placement. Compared to the conventional approach, it significantly reduced the operative time (50.36 vs. 61.58 min) and incision length (2.11 vs. 3.54 cm), while achieving comparable functional outcomes. These findings indicate that our minimally invasive approach has comparable effectiveness while reducing surgical trauma.