Authors: Li A, Ma Y, Chen Z, Lu Q, Liu C, Zhou P, Liang Q, Tao Y, Chen M, Chen Z, Luo F, Lei X, Liu S, Long J, Xiao H, Cui C, Ren Q, Liu Y, Zhong T, Liu J, Fan G, Liu Y, Hui Z, Chen Q, Liu Z
Frontiers in cardiovascular medicine
Neurodegenerative diseases (NDDs) are a group of chronic disorders characterized primarily by the progressive dysfunction and loss of specific neuronal populations. The major NDDs include Alzheimer’s...
Authors: Li K, Wang J, Zou L, Song X, Tong T, Chen J, Zhu S, Zhu J, Wang Y, Chu H
Frontiers in immunology
Idiopathic pulmonary fibrosis (IPF) is one of the most progressive interstitial lung diseases, and current therapeutics are known to slow disease progression, but not cure the disease []. Even though...
Authors: Yirsaw GT, Tafesse TB, Bune AJ, Amare SN
PloS one
Hypertensive disorders of pregnancy (HDP), including gestational hypertension, preeclampsia and eclampsia, are a leading cause of maternal and perinatal morbidity and mortality worldwide, affecting 5–...
Authors: Rosselli Z, Somville M, Ducoffre E, Arnould C, Bleyenheuft Y, Saussez G
JMIR research protocols
Cerebral palsy (CP) represents the most prevalent cause of physical disability in the pediatric population, affecting 1 to nearly 4 children in 1000 newborns worldwide [,]. This major public health pr...
Authors: Masuda-Suzukake M, Hasegawa M, Nonaka T
Acta neuropathologica communications
Hereditary transthyretin (ATTRv) amyloidosis with polyneuropathy (ATTRv-PN) is a rare, autosomal dominant, multisystem disorder caused by pathogenic variants in the () gene [, ], leading to misfoldin...
Authors: Alfaqeeh M, Zakiyah N, Postma MJ, Suwantika AA
BMC pregnancy and childbirth
Vitamin B12 (cobalamin) is a water-soluble vitamin which acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes involved in homocysteine remethylation and mitochondrial fatty...
Authors: Cao Y, Zhang Z, Gu X, Lu H, Wu J, Zhang C, Huang X, Qin H, Liu F, Liu Z, Tang B, Lu X, Ren H, Sun H, Wang R, Wang G
Cell death & disease
Hyperacusis is a debilitating auditory condition characterized by an abnormal sensitivity to everyday sounds, resulting in discomfort, pain, emotional distress, and functional impairment (). It freque...
Authors: Ziqin Z, Xin S, Yinjun G, Tingting L, Weilin F, Jin H, Jianwei LV
BMC urology
Atherosclerosis is now recognized as a chronic inflammatory disease, a concept with roots extending back to 1858 when Dr. Rudolf Virchow first described inflammatory cell infiltration in the arterial...
Authors: Sinkala A, Ngala EM, Mandona E, Lungu S
BMC pediatrics
With the expansion of tourism and economic development in high-altitude (HA) environments, more people are exposed to the negative health effects of HA conditions. Among the various environmental stre...
Authors: Jin J, Wang X, Zhao X, Wang H, Li Y, Liu Z, Yin T
Scientific reports
Multiple sclerosis (MS) is one of the most complex and disabling neurological diseases of our time, with an unpredictable course and multiple symptoms that can affect millions around the world (–). Th...
Authors: Vasilkov V, Liberman MC, Zhao Y, de Gruttola V, Polley DB, Maison SF
Ear and hearing
Central nervous system (CNS) disorders remain one of the most intractable global health burdens, featuring high morbidity, intricate pathophysiological mechanisms, and substantial clinical bottlenecks...
Authors: Krasselt M, Friedrich K, Braune L, Rothe K, Blüher M, Kovacs P, Dietrich A, Rossol M, Stumvoll M, Wagner U
International journal of obesity (2005)
In 1885, the German physician Friedrich Pelizaeus first described a familial disorder mainly characterized by nystagmus, developmental delay, spastic paraplegia, and ataxia []. Subsequently, in 1910,...
Authors: Chmiela T, Żur-Wyrozumska K, Mensah-Glanowska P, Strongosky AJ, Middlebrooks EH, Ayala E, Wszolek ZK
Journal of movement disorders
Chronic pain is a multidimensional clinical condition shaped by nociceptive input, peripheral and central sensitization, immune signaling, metabolic status, sleep, mood, movement behavior, and social...
Authors: Yadav S, Lee RX, Kajale SN, Joy B, Saha M, Patel P, Bull L, Cao S, Mitragotri S, Bono D, Sarkar D
Nature biotechnology
According to the latest , CHD affects an estimated 11.39 million individuals nationwide, with cardiovascular disease remaining the leading cause of death in both urban and rural populations. Excess bo...
Authors: Vallorani L, Balashova T, Cremon C, Vivarelli F, Canistro D, Morosini C, Paolini M, Rossi A
International journal of molecular sciences
Disorders of consciousness (DoC) are characterized by impaired arousal and awareness following severe brain injury (). Spasticity is a frequent complication in DoC, affecting approximately 59%–89% of...