A transcriptional atlas of gyrification reveals dynamic spatio-temporal gene expression in the developing ferret cortex.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the terminal follicular epithelium, with a worldwide prevalence of approximately 0.4%. It is characterized by inflammatory nodules and abscesses that may lead to the formation of persistent tunnels and scaring. Disease manifestations are typically symmetric with predilection sites, including the axillary, submammary, abdominal, inguinal, genital, and perianal regions. Pain is the predominant symptom; however, discharge, malodor, itch, and fatigue are also frequently reported by patients, with significant impairment on quality of life. Previous studies suggest that women are more often affected by HS than men, except in cases of perianal involvement, which demonstrates a male predominance. When HS is localized in the perianal region, Crohn disease (CD) should be considered as a differential diagnosis, particularly in the presence of fistulas or gastrointestinal symptoms. Previous studies have shown a significant association between HS and CD. Unlike other inflammatory skin diseases, surgical interventions play a key role in the treatment of HS, especially in moderate to severe disease where tunnels and scar tissue are present. Varies surgical techniques are used, including local and wide excision as well as deroofing, performed either with conventional surgery or CO laser.