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A Multi-Arm Two-Stage (MATS) Design for Proof-of-Concept and Dose Optimization in Early-Phase Oncology Trials

Authors: Zhenghao Jiang, Gu Mi, Ji Lin, Christelle Lorenzato, Yuan Ji

arXiv

The Project Optimus initiative by the FDA's Oncology Center of Excellence is widely viewed as a groundbreaking effort to change the $\textit{status quo}$ of conventional dose-finding strategies in onc...

mental health psychology open access

Difficult Lessons on Social Prediction from Wisconsin Public Schools

Authors: Juan C. Perdomo, Tolani Britton, Moritz Hardt, Rediet Abebe

arXiv

Early warning systems (EWS) are predictive tools at the center of recent efforts to improve graduation rates in public schools across the United States. These systems assist in targeting interventions...

mental health psychology open access

Evaluating Racialized Economic Segregation in the Presence of Spatial Autocorrelation

Authors: Yang Xu, Loni Philip Tabb

arXiv

Research on residential segregation has been active since the 1950s and originated in a desire to quantify the level of racial/ethnic segregation in the United States. The Index of Concentration at th...

mental health psychology open access

Guidance note on best statistical practices for TOAR analyses

Authors: Kai-Lan Chang, Martin G. Schultz, Gerbrand Koren, Niklas Selke

arXiv

The aim of this guidance note is to provide recommendations on best statistical practices and to ensure consistent communication of statistical analysis and associated uncertainty across TOAR publicat...

mental health psychology open access

A probabilistic approach for acoustic emission based monitoring techniques: with application to structural health monitoring

Authors: C. A. Lindley, M. R. Jones, T. J. Rogers, E. J. Cross, R. S. Dwyer-Joyce, N. Dervilis, K. Worden

arXiv

It has been demonstrated that acoustic-emission (AE), inspection of structures can offer advantages over other types of monitoring techniques in the detection of damage; namely, an increased sensitivi...

mental health psychology open access

A Bayesian Spatio-Temporal Extension to Poisson Auto-Regression: Modeling the Disease Infection Rate of COVID-19 in England

Authors: Pierfrancesco Alaimo Di Loro, Dankmar Boehning, Sujit Sahu

arXiv

The COVID-19 pandemic provided many modeling challenges to investigate the evolution of an epidemic process over areal units. A suitable encompassing model must describe the spatio-temporal variations...

mental health psychology open access

Sparsity-depth Tradeoff in Infinitely Wide Deep Neural Networks

Authors: Chanwoo Chun, Daniel D. Lee

arXiv

We investigate how sparse neural activity affects the generalization performance of a deep Bayesian neural network at the large width limit. To this end, we derive a neural network Gaussian Process (N...

mental health psychology open access

Association of stroke lesion distributions with atrial fibrillation detected after stroke

Authors: Yiming Chen, Sihui Wang, Dong Xu

arXiv

Background Atrial fibrillation is often missed by traditional intermittent electrocardiogram monitoring after ischemic stroke due to its paroxysmal and asymptomatic nature. The knowledge of the unique...

mental health psychology open access

Assessment of Anterior Cruciate Ligament Injury Risk Based on Human Key Points Detection Algorithm

Authors: Ziyu Gong, Xiong Zhao, Chen Yang

arXiv

This paper aims to detect the potential injury risk of the anterior cruciate ligament (ACL) by proposing an ACL potential injury risk assessment algorithm based on key points of the human body detecte...

mental health psychology open access

Restricted Mean Survival Time Estimation Using Bayesian Nonparametric Dependent Mixture Models

Authors: Ruizhe Chen, Sanjib Basu, Qian Shi

arXiv

Restricted mean survival time (RMST) is an intuitive summary statistic for time-to-event random variables, and can be used for measuring treatment effects. Compared to hazard ratio, its estimation pro...

mental health psychology open access

Quantitative bias analysis for outcome phenotype error correction in comparative effect estimation: an empirical and synthetic evaluation

Authors: James Weaver, Patrick B. Ryan, Victoria Y. Strauss, Marc A. Suchard, Joel Swerdel, Daniel Prieto-Alhambra

arXiv

Outcome phenotype measurement error is rarely corrected in comparative effect estimation studies in observational pharmacoepidemiology. Quantitative bias analysis (QBA) is a misclassification correcti...

mental health psychology open access

Creating Disasters: Recession Forecasting with GAN-Generated Synthetic Time Series Data

Authors: Sam Dannels

arXiv

A common problem when forecasting rare events, such as recessions, is limited data availability. Recent advancements in deep learning and generative adversarial networks (GANs) make it possible to pro...

mental health psychology open access

FastCod: Fast Brain Connectivity in Diffusion Imaging

Authors: Zhangxing Bian, Muhan Shao, Jiachen Zhuo, Rao P. Gullapalli, Aaron Carass, Jerry L. Prince

arXiv

Connectivity information derived from diffusion-weighted magnetic resonance images~(DW-MRIs) plays an important role in studying human subcortical gray matter structures. However, due to the $O(N^2)$...

mental health psychology open access

Design and Sample Size Determination for Multiple-dose Randomized Phase II Trials for Dose Optimization

Authors: Peng Yang, Daniel Li, Ruitao Lin, Bo Huang, Ying Yuan

arXiv

The conventional more-is-better dose selection paradigm, which targets the maximum tolerated dose (MTD), is not suitable for the development of targeted therapies and immunotherapies as the efficacy o...

mental health psychology open access

An anatomy-based V1 model: Extraction of Low-level Features, Reduction of distortion and a V1-inspired SOM

Authors: Suvam Roy, Nikhil Ranjan Pal

arXiv

We present a model of the primary visual cortex V1, guided by anatomical experiments. Unlike most machine learning systems our goal is not to maximize accuracy but to realize a system more aligned to...

mental health psychology open access