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A Network Object Method to Uncover Hidden Disorder-Related Brain Connectome

Authors: Shuo Chen, Yishi Xing, Jian Kang, Dinesh Shukla, Peter Kochunov, L. Elliot Hong

arXiv

Neuropsychiatric disorders impact functional connectivity of the brain at the network level. The identification and statistical testing of disorder-related networks remains challenging. We propose nov...

mental health psychology open access

Bayesian methods for event analysis of intracellular currents

Authors: Josh Merel, Ben Shababo, Alex Naka, Hillel Adesnik, Liam Paninski

arXiv

Investigation of neural circuit functioning often requires statistical interpretation of events in subthreshold electrophysiological recordings. This problem is non-trivial because recordings may have...

mental health psychology open access

Bayesian spike inference from calcium imaging data

Authors: Eftychios A. Pnevmatikakis, Josh Merel, Ari Pakman, Liam Paninski

arXiv

We present efficient Bayesian methods for extracting neuronal spiking information from calcium imaging data. The goal of our methods is to sample from the posterior distribution of spike trains and mo...

mental health psychology open access

Exact Spike Train Inference Via $\ell_0$ Optimization

Authors: Sean Jewell, Daniela Witten

arXiv

In recent years, new technologies in neuroscience have made it possible to measure the activities of large numbers of neurons simultaneously in behaving animals. For each neuron, a fluorescence trace...

mental health psychology open access

Organization and hierarchy of the human functional brain network lead to a chain-like core

Authors: Rossana Mastrandrea, Andrea Gabrielli, Fabrizio Piras, Gianfranco Spalletta, Guido Caldarelli, Tommaso Gili

arXiv

The brain is a paradigmatic example of a complex system as its functionality emerges as a global property of local mesoscopic and microscopic interactions. Complex network theory allows to elicit the...

mental health psychology open access

Local White Matter Architecture Defines Functional Brain Dynamics

Authors: Yo Joong Choe, Sivaraman Balakrishnan, Aarti Singh, Jean M. Vettel, Timothy Verstynen

arXiv

Large bundles of myelinated axons, called white matter, anatomically connect disparate brain regions together and compose the structural core of the human connectome. We recently proposed a method of...

mental health psychology open access

The connected brain: Causality, models and intrinsic dynamics

Authors: Adeel Razi, Karl Friston

arXiv

Recently, there have been several concerted international efforts - the BRAIN initiative, European Human Brain Project and the Human Connectome Project, to name a few - that hope to revolutionize our...

mental health psychology open access

Disentangling Brain Graphs: A Note on the Conflation of Network and Connectivity Analyses

Authors: Sean L. Simpson, Paul J. Laurienti

arXiv

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the univer...

mental health psychology open access

Mining within-trial oscillatory brain dynamics to address the variability of optimized spatial filters

Authors: Andreas Meinel, Henrich Kolkhorst, Michael Tangermann

arXiv

Data-driven spatial filtering algorithms optimize scores such as the contrast between two conditions to extract oscillatory brain signal components. Most machine learning approaches for filter estimat...

mental health psychology open access

A new fMRI data analysis method using cross validation: Negative BOLD responses may be the deactivations of interneurons

Authors: Hiroshi Tsukimoto, Takefumi Matsubara

arXiv

Although functional magnetic resonance imaging (fMRI) is widely used for the study of brain functions, the blood oxygenation level dependent (BOLD) effect is incompletely understood. Particularly, neg...

mental health psychology open access

What did we learn from forty years of research on semantic interference? A Bayesian metaanalysis

Authors: A. Bürki, S. Elbuy, S. Madec, S. Vasishth

arXiv

When participants in an experiment have to name pictures while ignoring distractor words superimposed on the picture or presented auditorily (i.e., picture-word interference paradigm), they take more...

mental health psychology open access

Using EEG-based brain connectivity for the study of brain dynamics in brain-computer interfaces

Authors: J. A. Gaxiola-Tirado

arXiv

The analysis of brain connectivity aims to understand the emergence of functional networks into the brain. This information can be used in the process of electroencephalographic (EEG) signal analysis...

mental health psychology open access

ABCD Neurocognitive Prediction Challenge 2019: Predicting individual residual fluid intelligence scores from cortical grey matter morphology

Authors: Neil P. Oxtoby, Fabio S. Ferreira, Agoston Mihalik, Tong Wu, Mikael Brudfors, Hongxiang Lin, Anita Rau, Stefano B. Blumberg, Maria Robu, Cemre Zor, Maira Tariq, Maria Del Mar Estarellas Garcia, Baris Kanber, Daniil I. Nikitichev, Janaina Mourao-Miranda

arXiv

We predicted residual fluid intelligence scores from T1-weighted MRI data available as part of the ABCD NP Challenge 2019, using morphological similarity of grey-matter regions across the cortex. Indi...

mental health psychology open access

Tracking fast and slow changes in synaptic weights from simultaneously observed pre- and postsynaptic spiking

Authors: Ganchao Wei, Ian H. Stevenson

arXiv

Synapses change on multiple timescales, ranging from milliseconds to minutes, due to a combination of both short- and long-term plasticity. Here we develop an extension of the common Generalized Linea...

mental health psychology open access

Behavior-dLDS: A decomposed linear dynamical systems model for neural activity partially constrained by behavior

Authors: Eva Yezerets, En Yang, Misha B. Ahrens, Adam S. Charles

arXiv

Brain-wide recordings of large-scale networks of neurons now provide an unprecedented view into how the brain drives behavior. However, brain activity contains both information directly related to beh...

mental health psychology open access