Transcription Factor Evolution Associated with Social Transitions in Blattodea.

Chronic pain is disabling and entails a variety of individual and public health challenges [-]. For people living with chronic pain, physical and psychological health and well-being are often affected, subsequently affecting quality of life (QoL) as well as the capacity for self-regulation [,-]. Recognizing the complex biopsychosocial aspects of pain [], treatment approaches, including self-management interventions such as cognitive behavioral therapy (CBT []) and the related acceptance and commitment therapy (ACT []), have been recommended and shown to be beneficial [-]. These usually in-person self-management interventions, however, are not always offered or available [], pointing to the potential of digital pain self-management programs to improve intervention access and outreach [-]. The current research team consequently designed and developed EPIO (ie, inspired by the Greek goddess for the soothing of pain, Epione), a digital self-management intervention for people living with chronic pain []. While digital health interventions show significant promise, a number of challenges have been identified, including limited or a lack of evidence-based content [,], limited or no stakeholder involvement during development [], challenges with adherence and attrition [,], inadequate proof of short- and long-term efficacy [,,,], and limited, if any, evidence of implementation into practice [,].