Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline.

Like many other neuroscientists, our ultimate goal is to understand how the brain works as an information-processing system that guides and orchestrates behavior. We seek to identify and understand how information is encoded, transformed, organized, integrated, stored, retrieved, communicated, and used to realize the many diverse functions of brains: perception, cognition, memory, decision-making, bodily regulation, learning, and motor action. Complementary to biophysical and dynamical systems models that predict trajectories of neural activity, we seek to connect patterns of neural activity with perceptual, cognitive, memory, and motor control functions. These involve signal-centric neurocomputational hypotheses, theories, and models of brain functions that underlie behavior. The current literature on oscillations, traveling waves, spatiotemporal patterns, and various neural codes in the brain is voluminous. Useful introductions to these fields and references to specific bodies of relevant research are cited in each of the Topic sections below.