Effect of Yoga on Immunity in Healthcare Professionals during the COVID-19 Pandemic - A Pilot Study.

Sotos syndrome is a rare genetic disorder that was first described in 1964. Sotos syndrome has been previously referred to as cerebral gigantism []. This term is now outdated and no longer used. It follows an autosomal dominant pattern of inheritance. Both men and women are equally affected. It occurs in all ethnic groups around the globe. This condition is reported to occur in about one in 14,000 live births. Sotos syndrome is characterized by a distinctive facial appearance, overgrowth, and varying degrees of macrocrania with an elongated skull shape (dolichocephaly). The facial phenotype is uniquely recognizable, typically presenting with a prominent high forehead (frontal bossing), down-slanting palpebral fissures, malar flushing, and a long, pointed chin that gives the face an inverted triangular appearance. Because the condition affects the development of the nervous system, affected children have learning disabilities or delayed mental and developmental abilities. Frequent behavioral problems include autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), different types of phobias, obsessions and compulsions, tantrums, and impulsive behaviors []. It is most frequently linked to mutations in the nuclear receptor-binding SET domain protein 1 ()geneand has an autosomal dominant inheritance pattern. All ethnic groups are affected, with an estimated incidence of one in 14,000 live births []. Sotos syndrome has been linked to a higher risk of malignancies, especially in childhood, including solid tumors and hematological malignancies, in addition to its distinctive phenotypic characteristics. The spectrum of reported neoplasms is wide, and early detection is crucial for prompt management even if the overall cancer risk is still quite low [,].