The CDK4/6 inhibitor abemaciclib attenuates cognitive impairment and neuroinflammation via DYRK1A in human tau transgenic mice.

Pregnancy-related low back and pelvic pain (LBPP) is a prevalent musculoskeletal condition affecting a substantial proportion of women during and after pregnancy []. The condition is associated with functional impairment, reduced quality of life, and the potential transition to chronic pain []. While most cases of LBPP resolve within the first three months postpartum, an estimated 15% persist beyond this period [], constituting a notable burden for affected individuals and healthcare systems []. Several studies in nonpregnant populations have suggested that low trunk muscle mass (TMM) may contribute to spinal instability and chronic back pain []. However, its relevance in postpartum populations remains unclear, particularly in the context of persistent postpartum LBPP (pp-LBPP). The physiological and biomechanical changes during pregnancy and delivery, including rapid weight gain and hormonal effects on ligaments and muscle tone, may exacerbate musculoskeletal vulnerability [, ]. Despite this, few studies have investigated whether postpartum TMM levels are associated with the persistence of LBPP following childbirth. In addition to physiological measures such as TMM, various obstetric and behavioral risk factors have been implicated in postpartum pain, including parity, delivery mode, and pre-pregnancy physical activity [, , ]. A better understanding of these risk factors may inform preventive strategies and help clinicians identify women at high risk for persistent symptoms. Therefore, this prospective study aimed to determine whether early postpartum TMM is independently associated with pp-LBPP and to identify other clinical and perinatal predictors of persistent symptoms.