Independent trajectories of cognitive function and daily events across 9 years during midlife and old age.

Disseminated histoplasmosis is caused by the dysmorphic fungus belonging to the genus, prevalent in immunocompromised patients with HIV (human immunodeficiency virus), malignant hematologic diseases, or those undergoing cytotoxic therapy . Of those individuals affected by disseminated histoplasmosis, 70 to 90% experience gastrointestinal involvement and only a small fraction are symptomatic. Common symptoms include fever, weight loss, abdominal pain, and diarrhea, while severe cases may present with gastrointestinal bleeding, masses, or lesions . Disseminated histoplasmosis occurs in 5 to 10% of cases, disseminating systemically to other organs, but is typically controlled by the immune system . The colon and ileum are the most frequently reported sites, although perforation of the jejunum is uncommon, with only three documented cases in the literature, according to Anderson . Except for the report by Goodwin all other cases involved HIV infection. This article presents the case of a patient with gastrointestinal histoplasmosis with jejunal perforation, apparently immunocompetent. In Colombia, only one case of peritoneal histoplasmosis in an acquired immunodeficiency syndrome (AIDS) patient has been reported . However, gastrointestinal histoplasmosis with jejunal perforation has not yet been reported, making this the first documented case in the country.