[DOT1L controls neuronal amyloid precursor protein expres-sion via the p38 MAPK-mediated mitochondrial dynamics homeostasis axis].

Today’s queer Canadian older adults grew up in an era when same-sex relationships were illegal. While Canada decriminalized homosexual acts in 1969, homosexuality remained classified as a mental disorder until 1973. Queer individuals were not permitted to serve in the military until 1992, and same sex marriage was not recognized until 2005 (). Life histories of discrimination contribute to psychological health disparities between queer and heterosexual individuals (). Queer Canadian older adults report poorer self-rated mental health and more mood disorders () and higher distress () than heterosexual peers. However, most prior work is cross-sectional, limiting understanding of long-term changes as individuals enter old age. Using propensity score matching, this study examines differences in the psychological health trajectories between lesbian, gay, bisexual, and heterosexual participants of the Canadian Longitudinal Study on Aging (CLSA; ). The Minority Stress Model posits that queer individuals carry an elevated mental health burden due to the unique, chronic, and socially imposed stressors associated with their minority status (). In line with this model, cross-sectional studies consistently point to poorer psychological health among queer older adults compared to their heterosexual counterparts (; ; ). However, evidence from the limited number of longitudinal studies is inconclusive. The United Kingdom Longitudinal Household Survey found persistent disparities between queer and heterosexual individuals aged 16 and older over a 10-year period, with bisexual women having the highest baseline distress, followed by gay and lesbian individuals; similar patterns emerged for life satisfaction (). In contrast, the Midlife in the United States Study found no baseline differences in life satisfaction between heterosexual, lesbian, and gay adults aged 20–75; life satisfaction increased over 18 years across groups except for bisexual adults, who showed a significant decline (). CLSA analyses collapsing lesbian and gay participants and comparing them to bisexual and heterosexual participants aged 44–88 show that gay/lesbian and bisexual individuals reported higher depressive symptoms and distress, and lower life satisfaction at baseline than heterosexuals; no group differences emerged in longitudinal trajectories (). The National Social Life, Health, and Aging Project in the United States found an increase in depressive symptoms over time among middle-aged and older heterosexual men and women, as well as sexual minority men, with no group differences in trajectories (). Hence, cross-sectional evidence suggests that queer individuals report poorer psychological health, but longitudinal findings are mixed, possibly due to significant heterogeneity within this population. Notably, among sexual minorities, bisexual individuals appear particularly vulnerable to poorer psychological health (; ). Bisexual individuals tend not to be welcome by either heterosexual, lesbian, or gay communities (). Prevalent biphobia—stigmatizing bisexuality as temporary, inauthentic, or immature—may further isolate bisexual older adults relative to their lesbian and gay counterparts (). Bisexual older adults tend to have fewer psychosocial resources (e.g., community belonging, social support) and report poorer psychological health than their lesbian and gay peers (; ). Given this heterogeneity in experiences, it is crucial to consider subgroup differences in psychological health trajectories to identify potential health disparities.