Adoption of App-Based Peer Support by Canadian Health Care Providers: Mixed Methods Organizational Implementation Study.

Neurodevelopmental disorders such as intellectual disability, global developmental delay, and autism significantly contribute to lifelong disability and mental health challenges globally []. Fragile X syndrome (FXS) is the leading inherited cause of intellectual disability and a major single-gene contributor to autism, resulting from cytosine-guanine-guanine (CGG) trinucleotide repeat expansion (>200 repeats) in the 5′ untranslated region (5’UTR) of the fragile X mental retardation 1 ( gene, resulting in gene silencing and reduced/absent fragile X mental retardation protein (FMRP) and subsequent synaptic dysfunction [–]. Beyond full mutation FXS, individuals carrying premutation alleles (approximately 55–200 CGG repeats) are at risk of Fragile X–associated premutation conditions, including Fragile X–associated primary ovarian insufficiency (FXPOI), Fragile X–associated tremor/ataxia syndrome (FXTAS), and Fragile X–associated neuropsychiatric disorders (FXAND), thereby extending the clinical and psychosocial burden of -related disorders also known as Fragile X disorders across the lifespan [,].