Therapeutic Potential of Solanum macrocarpon in Uterine Leiomyoma: In Vivo and In Silico Approaches.

With the significant increase in global life expectancy, the continuous expansion of the older population has become an undeniable social phenomenon. According to the United Nations’ World Population Prospects 2024, the number of people aged 65 years and older worldwide is projected to reach 2.2 billion by the late 2070s, surpassing the number of children below the age of 18 years []. This profound demographic shift poses sustained pressure on health care systems and creates an urgent need for scalable strategies that strengthen older adults’ health literacy and access to health information []. Health communication is one of the most cost-effective public health strategies for translating health knowledge, promoting behavioral change, and enhancing health literacy [-]. For older adults specifically, health communication not only facilitates their reception, understanding, and application of personalized health information, but also influences their attitudes and cognition, thereby promoting health behavior change and achieving health promotion outcomes []. The rapid advancement of digital technologies, including AI, virtual and augmented reality, and machine learning, has transformed how health communication is practiced []. Digital technology mediates and embeds itself within everyday social life and human communicative behavior, reshaping individuals’ experiences of time and space, as well as physical and mental dimensions, and subject-object relationships through technological participation [], creating a dynamic, multidimensional ecosystem through which health information now circulates []. However, older adults face a wider digital gap than younger groups, along with intergenerational communication barriers and information-cocoon effects, which can deepen their isolation and widen health inequalities [,-]. In this review, “older adults” refers to people aged 50 years or older. This threshold follows the operational definition adopted by the World Health Organization’s (WHO)’s Study on Global Ageing and Adult Health (SAGE) []. It is also consistent with recent qualitative reviews on digital aging that adopt this threshold to capture the wide range of experiences from the early-old to the oldest-old []. Digital health communication refers to the use of digital technologies, such as mobile health apps, telehealth platforms, patient portals, social media, and online health communities, to support the exchange, dissemination, and acquisition of health information among older adults, health care providers, and peers [,]. This focus is distinct from the category of digital health interventions that actively manage clinical or behavioral outcomes, such as remote monitoring, digital therapeutics, and AI-based clinical decision support [,]. Existing qualitative syntheses have offered valuable insights into this field, yet have largely approached it from particular angles. Much of this work has centered on the determinants of adoption or on effectiveness: Aslan et al [] used meta-ethnography to identify the barriers and facilitators of older adults’ adoption of communicative e-health services in clinical encounters, and reviews of digital health technologies similarly emphasized effectiveness within clinical care pathways [,]. Other reviews have examined health communication within specific care or interaction settings, such as home health care services [] and primary care settings []. Across this body of work, 3 issues remain underexamined. First, the community has been treated mainly as a backdrop, rather than as the everyday setting in which older adults access, share, and make sense of health information. Second, older adults’ experiences of trust and responsibility have been examined chiefly at the point of technology adoption, rather than across the fuller communicative process that follows. Third, the communicative use of digital technology has rarely been disentangled from its use as a clinical or behavioral intervention. As digital health platforms are now embedded in routine community life [] and continue to reshape how older adults reach health information [], an updated qualitative synthesis focused specifically on community-based digital health communication is warranted.