Radiation cognition, government trust and their potential influencing factors in residents within 30 km of Qinshan nuclear power plant.

L. [Cannabaceae] has a documented history of medicinal use spanning thousands of years across diverse cultural and geographic contexts, with traditional applications encompassing pain relief, mood modulation, sleep induction, and the management of inflammatory and neurological conditions (; ). In Brazil, the therapeutic use of -based products has been formally recognized within the national regulatory framework since 2015, with subsequent updates consolidating the supervised clinical use of cannabinoid-based botanical drugs for a broad spectrum of chronic conditions (ANVISA RDC No. 327/2019 and RDC No. 660/2022). The growing integration of into contemporary clinical practice reflects both the long-standing ethnopharmacological tradition associated with this species and the expanding body of evidence supporting the pharmacological activity of its principal phytocannabinoid metabolites, tetrahydrocannabinol (THC) and cannabidiol (CBD) (; ). The endocannabinoid system plays a central role in the regulation of multiple physiological and behavioral processes, including nociception, mood, sleep, stress response, and subjective perception of wellbeing, primarily through activation of cannabinoid receptors CB1 and CB2, widely distributed in the central and peripheral nervous systems (; ). This system acts as a fine homeostatic modulator, integrating neural, endocrine, and immunological signals (). Based on this biological framework, products derived from , especially those containing cannabidiol (CBD) and tetrahydrocannabinol (THC), have been investigated as potential therapeutic interventions for various chronic clinical conditions, including chronic pain syndromes, with distinct and complementary mechanisms of action (; ; ). Over the past few decades, the use of has expanded, driven by regulatory changes, greater acceptance in clinical practice, and growing appreciation of patient-centered outcomes (; ). Systematic reviews and broad-scope studies suggest that cannabinoids may be associated with benefits in conditions such as chronic pain, anxiety, and sleep disorders; however, the magnitude and consistency of these effects vary substantially according to formulation, dose, clinical profile of patients, and context of use (; ; ). This variability reinforces the need for assessments that transcend exclusively biomedical outcomes and incorporate the subjective patient experience.