Provoked cytokine response is not associated with distress or induced secondary hyperalgesia in people with suppressed HIV.

The treatment of overweight and obesity is multifactorial and typically involves recommendations to reduce energy intake and increase physical activity as well as receive support for behavior change []. In addition, group-based weight loss treatment is often more effective than individual treatment [], partly due the social support provided in a group treatment setting []. There has been an increase in behavioral interventions for weight loss being delivered entirely remotely, partly driven by the coronavirus disease of 2019 (COVID-19) pandemic []. Electronic or mobile health (eHealth/mHealth) interventions for weight loss can provide easy access to tools for diet, physical activity, and weight self-monitoring as well as delivery of intervention content and goal setting with feedback [, ]. Replicating the group support that is provided in traditional face-to-face behavioral weight loss treatment has been more difficult. Studies have utilized a wide range of methods to help participants engage in social support with one another, such as social media groups [], text messaging [], and group chat []. Despite these efforts, maintaining engagement with social support features in mHealth/eHealth interventions has been challenging with many studies showing a decline in engagement over time []. One potential way to encourage engagement with social support features in an mHealth intervention is to leverage gamification. Gamification, which uses elements of game design (points, badges, leaderboards) in nongame settings, has been used in public health interventions, including those that target diet and physical activity []. In particular, social gamification may focus on things like financial incentives to gamify an intervention or facilitate support []. While previous weight loss interventions have used financial incentives with varying degrees of success [, ], these incentives can be costly. Provision of points for behaviors is a scalable and low-cost way to provide incentives. However, few weight loss interventions have isolated the use of points to incentivize the social support provision needed for successful weight loss [].