Circulating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer's disease.

The World Health Organization has reported that low levels of physical activity influence the risk of developing cancer, including colorectal cancer. For general health purposes, including the risk of malignant tumors, WHO recommends 150–300 min per week of aerobic physical activity at a medium level for adults. Prehabilitation before surgery has been tested for different types of abdominal cancer, but a systematic review found that considerable differences in prehabilitation programs of physical activity with or without other components made it impossible to reach a firm overreaching conclusion []. For patients diagnosed with colorectal cancer, prehabilitation before treatment has been hypothesized to improve outcomes, such as physical strength, recovery and risk of postoperative complications. As described in a recent meta‐analysis on unimodal high or moderate intensity training in patients with colorectal cancer studies have come to different results []. Randomized trials with multicomponent interventions in frail patients with major abdominal or colorectal cancer surgery have reported conflicting results on impact on complications after surgery [, ]. In PHYSSURG‐C, a randomized, controlled, multicenter superiority trial with the aim to improve short term recovery, an intervention of increased physical activity before surgery for colorectal cancer as well as after discharge, found no difference in self‐reported physical recovery at four weeks postoperatively in the intervention group compared to routine care []. Cancer treatment often leads to fatigue, a state of tiredness that is not improved by resting. A review of 11 studies with low level of bias reported improvement of fatigue after supervised exercise training []. In a multicentre international cohort of patients operated for rectal cancer, we found an association between pain and fatigue with global quality of life []. Reviews suggest that fatigue and mental health can improve after physical training, specifically in patients with cancer [, ]. In patients treated with adjuvant chemotherapy after surgery for breast cancer, a program of high‐intensity interval and resistance training was found superior to usual care regarding fatigue, pain, and emotional function [].