Pathological Classification and Clinical Characteristics of Growth Hormone-Secreting PitNETs.

Diabetes and prediabetes increase the risk for, and often co-occur with, atherosclerotic diseases including peripheral artery disease (PAD), and these conditions increase the risk of hospitalization (,). On the other hand, engaging in physical activity (PA) and reducing sedentary behavior (SB) have been shown to reduce risk of mortality (,), cardiovascular disease (,), and hospitalizations (,). Whether these findings pertaining to PA and SB apply equally to adults with chronic disease is unclear. Indeed, some prior evidence suggests that the benefits of greater PA and lesser SB may be stronger among relatively healthy individuals, as compared with those who are older or have chronic diseases (,). Recent work in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) showed that meeting recommended targets () for moderate to vigorous physical activity (MVPA) was associated with lower risk of mortality and cardiovascular disease events among those with normoglycemia, but not in those with prediabetes (). Another recent HCHS/SOL study examined the association between ankle brachial index (ABI), tertiles of activity and all-cause mortality. That study found increased mortality risk for those with abnormal ABI and lower light intensity physical activity (LPA) or higher SB levels, jointly and independently (). Alongside multiple known health benefits of PA, potential reduction in hospitalization risk is also important. Adults with comorbidities carry a greater hospitalization burden than those without them (,). Hospitalizations represent a large financial burden, with an average adjusted cost of $14,101 per inpatient stay at community hospitals in 2019 (), and costs are often higher for those with multiple chronic conditions ().