Bedside Intraoral Scanning to Reduce Procedural Burden in Older Adults With Dementia: Nonrandomized Counterbalanced Crossover Feasibility Study.
Authors: Hillebrecht AL, Vach K, Maurer C, Kohal RJ, Spies BC
Journal: JMIR formative research
mental health
psychology
open access
Abstract
Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV), is a leading cause of morbidity and mortality in young cats and represents the most common infectious cause of central nervous system (CNS) disease in this species. It occurs in 2 main forms: the effusive (wet) form, characterized by abdominal or thoracic effusions, and the non-effusive (dry) form, which is associated with granulomatous lesions. Neurologic involvement is more frequently associated with the non-effusive form, with up to 38% of affected cats exhibiting neurologic signs. Neurologic FIP typically presents as focal or multifocal CNS syndromes. Three predominant clinical patterns have been reported: multifocal CNS disease, central vestibular syndrome, and T3-L3 myelopathy. The most common neurologic deficits include abnormal mentation, tetraparesis, pathologic nystagmus, and vestibular ataxia. Magnetic resonance imaging (MRI) is considered a highly sensitive tool for detecting neurologic FIP, particularly when interpreted in conjunction with signalment and cerebrospinal fluid (CSF) analysis. Typical MRI features include obstructive hydrocephalus, meningeal, and ependymal contrast enhancement (commonly bilateral and symmetrical) and intramedullary T2W hyperintensity, consistent with syringomyelia, in the cranial cervical spinal cord. Additional findings may include indicators of increased intracranial pressure, such as foramen magnum herniation and mass effect. Incomplete suppression of CSF signal on fluid-attenuated inversion recovery (FLAIR) sequences also may be observed, reflecting increased protein content or inflammatory debris within the CSF. Although MRI is considered the modality of choice for evaluation of neurologic FIP, computed tomography (CT) also may identify brain changes such as ventriculomegaly, mass effect, and meningeal changes. Nonetheless, lower sensitivity for detection and characterization of parenchymal lesions has been reported with this technique compared with MRI.