The case for targeting enhancer regions in high-risk TCF3::HLF-positive B-cell acute lymphoblastic leukemia.

Globally 57 million people live with dementia and around 10 million new cases of dementia are reported each year (). In Canada, approximately 771,939 individuals are living with dementia, and the number is expected to increase to 1 million by 2030 (). Provincially, similar trends can be seen in British Columbia (B. C.), Canada, where the estimated number of cases will increase from 85,800 in 2022 to 247,300 by 2050 (). The increased prevalence of persons living with dementia around the world emphasizes the urgency to create supportive and caring communities that can foster maintenance of independence and social engagement as long as possible and delay potential need for institutional relocation. Dementia-friendly communities (DFCs) aim to reduce stigma, improve accessibility and mitigate challenges related to living with cognitive impairment. Dementia-friendly environments can be created through supportive infrastructures (e.g., safe and accessible sidewalks, benches, landmarks for spatial orientation), national policies (e.g., early screening, caregiver education), and inclusive services and programs (e.g., community-based programs, services, activities) (, ). Initiatives like Alzheimer’s Cafés and memory-friendly walking groups have shown success in promoting social engagement and well-being of older adults living with dementia (, ). However, maintaining out-of-home participation and activities can be challenging for people living with dementia, due to decline in cognitive functioning over time, built environmental barriers, and underlying societal stigma (). Social participation is important for maintaining independence and reducing the level of social isolation; however, existing assessment tools prioritize in-home activities or dementia caregiver proxies, neglecting community involvement (). The “Participation in Activities and Places Outside Home for Older Adults” (ACT-OUT) survey addresses this gap by evaluating out-of-home engagement across four domains of places, including: (A) consumer, administrative, and self-care places; (B) places for healthcare; (C) social, spiritual, and cultural places; and (D) places for recreational and physical activities. The full list of the destinations is provided in (, ).