Relating movement behaviours and non-motor characteristics in people with Parkinson's disease: A compositional data analysis approach.

Donkeys () are rustic animals whose importance is often neglected due to their specific characteristics, both in morphophysiological and pharmacological perspectives, as well as their temperament. Thus, some studies have evaluated the effects of drugs on donkeys., However, protocols for this species are still scarce. It is common to administer drugs to chemically restrain equids, avoiding the complications and costs of general anaesthesia. The adrenergic alpha‐agonist drugs produce sedation, analgesia, and muscle relaxation despite their adverse effects, such as bradycardia, hypotension and decreased gastrointestinal motility., , Among adrenergic alpha‐agonists, xylazine is the shortest acting and may result in insufficient analgesia for some surgical or outpatient procedures in monotherapy. In these circumstances, they are administered in association with opioids or with local blocking techniques to improve analgesia. Opioids are useful in anaesthesiology because of their ability to decrease sympathetic and somatic responses to harmful stimulation. Combinations of an alpha‐agonist with an opioid in single or repeated administrations, or even as part of a peri‐anaesthetic protocol, can provide synergistic analgesic effects and good sedation. This association reduces the potential for excitation at the level of the central nervous system.