Evaluating an online-delivered resistance exercise intervention for racially diverse breast cancer survivors using the RE-AIM framework.

Suicide is a major public health issue worldwide, causing around 700,000 deaths each year (). In Latin America, suicide accounts for ~45,000 deaths annually (age-standardized rate of 5.23/100,000 inhabitants). Between 2010 and 2016, while global suicide rates declined by 9.8%, rates in Latin America increased by 6% (, ). This increase was particularly pronounced between 1990 and 2019, with the largest increases in Paraguay (268.2%), Ecuador (245%), and Mexico (189%) (). Consistent with global trends, suicide rates in Latin America are highest among older adults (>70 years) and markedly higher in men, with a male-to-female ratio of 3.28, significantly higher than the global ratio of 1.8 (, ). These increased rates have been linked to a complex interplay of cultural, behavioral, and socio-economic factors, including poverty, violence, and inequality, highlighting the urgent need to better understand suicide in the Latin American context (, ). Multiple factors contribute to suicidal behavior, including biological, psychological, and environmental influences (, ). In recent years, there has been considerable progress in understanding the biological basis of suicidal behavior (, , ). However, most research in this area has focused on European ancestry populations, limiting its generalizability to other ancestry groups (, ). Environmental exposures and genetic architecture differ across populations. Latin American populations are highly admixed, with diverse contributions from Indigenous, European, and African ancestries (–). This genomic diversity provides unique opportunities to uncover ancestry-specific mechanisms of suicidal behavior. However, Latin American and Hispanic/Latinx populations remain severely underrepresented in suicide genomics (, ).