Glutamate- and GABA-targeted drugs for Cc-occurring bipolar and alcohol use disorders: a randomized, double-blind, placebo-controlled, crossover study of N-acetylcysteine, gabapentin, and placebo.

Implantable collamer lens (ICL) surgery has become an important surgical approach for myopia correction in recent years because of its good visual quality and minimal impact on corneal biomechanics and its safety has been well-proven [, ]. The common complications of ICL include subcapsular cataract, increased intraocular pressure, pigment diffusion, pupillary block, and decreased corneal endothelial cell count. Most of these complications occur in the early postoperative period and are often related to factors such as abnormal arch height, mechanical contact between the ICL and intraocular tissues, and inflammatory reactions []. Iridocorneal endothelial syndrome (ICE) is a rare unilateral disease characterized by the abnormal proliferation and migration of corneal endothelial cells, which leads to progressive peripheral anterior synechiae (PAS), structural changes in the iris, corneal edema, and secondary glaucoma []. The pathogenesis of ICE is not fully understood, but it is currently believed to be related to factors such as endothelial cell phenotypic transformation and viral infection []. The clinical progression of ICE is usually chronic and gradual, with no obvious symptoms for a long period until the development of corneal decompensation or glaucoma []. No case of ICE has been reported after ICL implantation, and the relationship between the two remains unclear. This study reports a case in which ICE occurred 4.5 years after ICL implantation.