The Effect of Semaglutide on Quality of Life in Adults With Overweight or Obesity: A Brief Systematic Review and Meta-Analysis.

The most important attributes of acute migraine therapy include efficacy, tolerability, and consistency of response []. Although efficacy and tolerability are routinely assessed in clinical trials, consistency of response is less frequently evaluated []. Consistency can be used to refer to several distinct aspects of acute migraine therapy. It can refer to the efficacy across subgroups of patients defined by characteristics such as age, biological sex, race, ethnicity, or comorbidities. In this context, consistent treatment is one with similar effect across subgroups. Consistency at the population level can also describe the change in efficacy across multiple uses, as measured by the proportion of patients achieving a specified endpoint in sequential attacks. Consistency can also be evaluated at the patient level (within patient) to describe the proportion of treated attacks that respond to treatment. For patients, a treatment that provides reliable effectiveness brings predictability to their lives. Knowing they will be able to quickly return to planned activities should a migraine attack occur provides benefits both at the time of an attack and between attacks. This often leads to higher treatment satisfaction and longer persistence on treatment []. Confidence in acute migraine treatment has been associated with better social functioning, improved mental health, and an overall higher quality of life []. Within patient consistency translates into having treatment that can be relied on to work every time it is used. Medications with consistently positive outcomes reduce the need to overuse or layer medications to ensure effectiveness []. Within patient consistency is similarly important for healthcare professionals. It describes how predictable the treatment response will be for a particular patient. Treatments that work in some patients or only on some occasions can be difficult to use in clinical practice. A high level of within patient consistency makes it easier to optimize treatment and reduces the number of healthcare visits required to manage migraine [, , ].