Psychometric Validation of a User-Centered Usability and Acceptance Instrument for Home-Based Cognitive Rehabilitation in Older Adults With Cognitive Impairment.

Dementia is an irreversible neurodegenerative disorder characterized by cognitive dysfunction, depressive symptoms, behavioral and psychological disturbances, and impairments in activities of daily living (ADL). Globally, it ranks as the fifth leading cause of mortality and the most burdensome disease in terms of disability-adjusted life years (). The global prevalence of dementia is escalating rapidly, with projections estimating 82 million cases by 2030 and 152 million by 2050 (). Cholinesterase inhibitors are widely prescribed to alleviate cognitive symptoms in dementia patients; however, 20%−30% of those treated experience adverse effects, including gastrointestinal discomfort (abdominal pain, nausea, vomiting) and anorexia. These limitations highlight the need for non-pharmacological interventions (NPIs), which demonstrate superior safety profiles and efficacy in managing cognitive decline, ADL dysfunction, and neuropsychiatric symptoms across dementia subtypes (). The World Alzheimer Report 2022 underscores that diagnosis represents merely the first step in the dementia care continuum (). Integrated treatment, care, and support constitute the cornerstone of effective post-diagnostic models, with early-stage interventions—implemented with precision and adherence to evidence-based protocols—yielding substantial economic benefits (). Nurses frequently serve as the primary contact in post-diagnosis care planning, treatment delivery, and ongoing monitoring, playing a pivotal role in supporting individuals with Alzheimer's disease (AD) and their caregivers.