Effect of increasing cognitive activity participation via calligraphy practice on salient network and central executive network in older adults with subjective cognitive decline: a secondary analysis

Prostate cancer is the most commonly diagnosed cancer in Australia, contributing to a significant cause of cancer‐related death. While radical therapies of prostate cancer are effective, they are associated with significant morbidity, such as urinary incontinence and erectile dysfunction. This has led to a shift in less invasive approaches that maintain oncological control while preserving quality of life. Focal therapy (FT) is an emerging approach that aims to target index lesions to achieve cancer control and reduce treatment‐related side effects. However, accurate identification of tumour location, grade and burden, and therefore patient selection, is critical for FT success. Although there is a diversity of guidelines available for patient selection, prostate biopsy and MRI currently represent the standard diagnostic tools to guide FT. Nonetheless, these modalities remain imperfect. Despite these pretreatment tests, 21% of patients have cancer recurrence within the treated area, and outfield recurrence occurs in approximately 10%. While infield recurrence may be suggestive of failure of ablation and outfield recurrence lends to selection failure, ultimately accurate characterisation of tumours is critical. Inadequate characterisation of multifocal, bilateral or clinically significant lesions may lead to compromised treatment outcomes. Prostate‐specific Membrane Antigen (PSMA) PET imaging has recently transformed the diagnostic and therapeutic landscape of prostate cancer care. Initially introduced as a staging modality for high‐risk disease, PSMA PET has demonstrated superior sensitivity and specificity compared to conventional imaging in detecting both locoregional and metastatic lesions. Beyond staging, there is growing evidence to support its role in primary tumour localisation and characterisation. It therefore offers to be a valuable adjunct to current diagnostics and refine selection of patients for FT. The aim of this study was to evaluate if PSMA PET can enhance detection rates of index prostate lesions for focal therapy.