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Early Visual, Refractive, and Astigmatism Vector Outcomes of StreamLight Trans-PRK for High Astigmatism (≥ 2.00 D).

Authors: Prodescu SV, Curcă PF, Tătaru CP, Tătaru CI
Journal: Romanian journal of ophthalmology
mental health psychology open access

Abstract

We searched PubMed, Ovid, Embase, and medrxiv for studies reporting association between maternal anaemia and stillbirth. We used search terms synonymous with maternal anaemia, haemoglobin, and stillbirth, but restricted the search to studies between January 2000 and April 2026, although some studies have shown association between maternal anaemia and the risk of stillbirth in India, there is limited generalisable evidence originating from diverse setting across varying severity of anaemia and different trimesters. Our study leverages a multi-cohort dataset of pregnant women with known birth outcomes from the Stillbirth Pooled Indian Cohort (ICMR-SPIC consortium), to understand the association between severity of maternal anaemia and the risk of stillbirth. The dataset consists of nearly 220,000 pregnant women from ten cohorts across the country representing different states, communities, and urban and rural regions. This study leverages different statistical and regression methods to account for potential confounders across all cohorts to provide a pooled risk estimate. We found that maternal anaemia (haemoglobin levels <10 g/dL) at any point in the pregnancy is associated with the increased risk of stillbirth after 28 weeks of gestation, in India compared to no/mild anaemia (≥ 10 g/dL). Women with mild anaemia did not have increased risk for stillbirth except during the 2nd trimester. Stillbirths occurred earlier in gestation among those with severe anaemia at a median of 29 weeks of gestation while it was 31 weeks for moderate/mild/no anaemia.