Novel protein acylations in Alzheimer's disease: Molecular, mechanisms, biological significance, and diagnostic and therapeutic potentials.

Cortical or cerebral visual impairment (CVI) is a leading cause of visual impairments in children in developed countries (). CVI is caused by damage to postgeniculate visual pathways in the brain and results in abnormalities of visual function that cannot be adequately explained by any ocular comorbidities (; ). The most common etiology of CVI is generally reported to be hypoxic ischemic encephalopathy; other etiologies include prematurity with periventricular leukomalacia, infections, metabolic or genetic disorders, seizures, structural brain abnormalities, head trauma, hydrocephalus, and in utero drug exposure (; ; ). Children with CVI are often multiply disabled, and they frequently have ocular and neurologic comorbidities in addition to developmental delays. Common ocular comorbidities include strabismus, optic atrophy, and nystagmus, while cerebral palsy and seizures are common neurologic comorbidities (; ; ; ; ; ). Thus, there are multiple factors that could reduce quality of life in children with CVI. However, there are limited data using validated assessments of vision-specific quality of life (VS-QOL) in these patients. Moreover, the effect of commonly used measures of visual function, such as visual acuity, on quality of life in CVI is largely unexplored. Therefore, we administered a validated pediatric VS-QOL questionnaire to caregivers of children with CVI to characterize VS-QOL in these patients and determine which clinical factors were most strongly correlated with VS-QOL scores. Our specific research questions were: Is VS-QOL decreased in children with CVI compared to typically developing children? and