Mesencephalic astrocyte-derived neurotrophic factor suppresses ferroptosis to alleviate depressive-like behaviors via the PERK/ATF4 signaling pathway.
Authors: Dang R, Wang P, Li W, Wang M, Chen Y, Xiang Y, Fan L, Ren Y, He Y, Xie P
Journal: Redox biology
mental health
psychology
open access
Abstract
The term “orthoplastic surgery” was first widely used by Dr. L Scott Levin in 1993 to
describe an approach to extremity reconstruction that incorporated the core
principles of both plastic and orthopedic surgeries
. Orthoplastic surgery emphasizes the
importance of a multidisciplinary surgical approach originating in the care of
extremity trauma and has now extended to managing complex oncologic defects, chronic
wounds and vasculopathic lower extremity conditions. Orthoplastic surgery relies on collaboration and coordination across many other
disciplines, including vascular surgery, interventional radiology, rehabilitation
medicine, oncology, infectious diseases, rehabilitation services, and social work.
Specialists must work in concert, as these injuries often require the meticulous
management of infection burden, vascular compromise, tissue loss, and extensive
postoperative rehabilitation to optimize surgical salvage outcomes. A pivotal study by Godina et al marked a critical development in the evolution of
orthoplastic surgery, demonstrating that early soft tissue coverage, preferably
within 72 hours of injury, significantly reduces the likelihood of developing major
complications, including flap failure and infection
. The advent of negative pressure therapy
and later investigations of the timing of soft tissue coverage reinforce Godina’s
findings and have further suggested that successful surgical outcomes may still be
achieved when tissue coverage is performed beyond the 72-hour window
describe an approach to extremity reconstruction that incorporated the core
principles of both plastic and orthopedic surgeries
. Orthoplastic surgery emphasizes the
importance of a multidisciplinary surgical approach originating in the care of
extremity trauma and has now extended to managing complex oncologic defects, chronic
wounds and vasculopathic lower extremity conditions. Orthoplastic surgery relies on collaboration and coordination across many other
disciplines, including vascular surgery, interventional radiology, rehabilitation
medicine, oncology, infectious diseases, rehabilitation services, and social work.
Specialists must work in concert, as these injuries often require the meticulous
management of infection burden, vascular compromise, tissue loss, and extensive
postoperative rehabilitation to optimize surgical salvage outcomes. A pivotal study by Godina et al marked a critical development in the evolution of
orthoplastic surgery, demonstrating that early soft tissue coverage, preferably
within 72 hours of injury, significantly reduces the likelihood of developing major
complications, including flap failure and infection
. The advent of negative pressure therapy
and later investigations of the timing of soft tissue coverage reinforce Godina’s
findings and have further suggested that successful surgical outcomes may still be
achieved when tissue coverage is performed beyond the 72-hour window