Comorbid mechanisms of psoriasis and mental disorders: an analysis of inflammatory and psychosocial interactions.

The 11th edition of the International Classification of Diseases released by the World Health Organization classifies depression as a depressive disorder (). As a psychological disease, depression is clinically characterized by persistent low mood or a significant decrease in interest and pleasure, accompanied by cognitive, behavioral or neurological symptoms, which can seriously damage the individual's socio-psychological function (). There is evidence that the pathogenesis of depression involves the complex interaction between neurotransmitter disorders though, genetic susceptibility and environmental stressors, the current diagnostic practice still relies mainly on clinical interviews and standardized assessment scales (). In the 2025 publication of World Health Organization , it is noted that in 2021, depressive disorders alone were the second leading cause of global years lived with disability(YLDs), accounting for 6.2% of all YLDs (). Severe depression is also one of the important factors in global incidence and mortality (). In modern society, the accelerated pace of life and increased stress are closely related to the increase in the prevalence of depression (). Although public awareness of depression has increased recently, serious cognitive bias and social discrimination still exist (). Simply attributing depression to “low mood” or “emotional vulnerability” ignores the complexity of depression as a biological psychosocial systemic disease. This misunderstanding leads to self-stigmatization and social prejudice (), often delaying patients from seeking help and receiving appropriate treatment (). Increasing public awareness of mental health has now increased the demand for psychological counseling, especially among young people (). They are more willing to seek professional help. Against this background, the short video platform has become an important channel for health communication and public education (). Chinese mainstream platforms such as TikTok and Bilibili play a unique role in disseminating health information related to depression (). These platforms are becoming increasingly important on the Internet. The video platform gathers rich resources covering causes, symptom identification, treatment plans and rehabilitation stories (). Not only do these contents about depression have the potential to improve public mental health literacy, but they can also reduce social discrimination and build a mutual online community (, ).