Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model.

Authors: Hagenbeek TJ, Zbieg J, Smith R, Paul S, Gerosa L, Torrini C, Guarnaccia AD, Ong C, Lacap JA, Ning M, Sodir NM, Hafner M, Tremblay J, Hawley J, Chan B, Verma VA, Beveridge RE, Hsu PL, Ulas G, Wang L, Nonomiya J, Chen S, Pham V, Webster J, Preston J, Hung J, Eastham J, Dunlap D, Lee W, Beroza P, Nayyar N, Martin S, Lin E, Weng J, Foster SA, Shanahan F, Fong R, Boenig G, Di Lello P, Kubala MH, Hunsaker T, Ravichandran M, Saenz-Lopez Larrocha P, Lau J, An L, Levy E, Lorenzo MN, Lill JR, Modrusan ZD, Chen YC, Yao X, Brastianos PK, Maddalo D, Dey A

Journal: Nature communications