High-dimensional Parameter Transfer With Fused-Regularizer.

Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome that can be difficult to diagnosis. Paraneoplastic ocular syndromes can present with visual loss including MAR, cancer-associated retinopathy (CAR), paraneoplastic uveitis, and paraneoplastic optic neuropathy. In MAR, self-antigens of the eye, expressed by the melanoma, may trigger the production of antiretinal antibodies. This ‘molecular mimicry’ is the presumed underlying mechanism for the development of ocular paraneoplastic syndromes (). Classic symptoms in MAR include photopsia, nyctalopia, and visual field loss (). Characteristic electroretinography (ERG) findings (e.g., decreased b-wave) in MAR occur due to bipolar cell dysfunction. Most cases of MAR, however, have a known diagnosis of melanoma. We describe a 71-year-old woman who presented with progressive vision loss in both eyes (OU) and a posterior uveitis OU due to paraneoplastic MAR from an undiagnosed occult non-cutaneous soft tissue melanoma. A 71-year-old Caucasian female presented with a six-month history of bilateral simultaneous flashes and floaters. Past medical history included hypertension managed with lisinopril, and hypothyroidism for which she was on replacement levothyroxine. The remainder of the past medical, surgical, social, family, and medication history were non-contributory. She had no known prior cancer or melanoma history. Fundus examination at the initial presentation Sub foveal multifocal yellow deposits with mild RPE mottling (). Fundus photograph initial presentation showing dense vitritis in both eyes.