Achieving the triple endpoint of body weight reduction thresholds, systolic blood pressure reduction ≥5 mmHg and non-HDL cholesterol <130 mg/dL with tirzepatide in people with obesity: A post hoc anal
Authors: Sattar N, Srinath R, García-Pérez LE, Lee CJ, Karanikas CA, Chen X, Plat A
Journal: PloS one
anxiety disorders
mental health
open access
Abstract
Heterocycles are fundamental
scaffolds in the design of new bioactive
compounds in medicinal chemistry, owing to their structural diversity
and the fact that many of them participate in a wide range of biochemical
processes. Their significance arises from the extensive variability
in ring size, the number and nature of the heteroatoms, which may
include one or more, and the incorporation of diverse functional groups
in the ring structure. Altogether, these features make heterocyclic
chemistry particularly attractive. Among the most extensively investigated
heterocycles, nitrogen-containing systems have gained increasing prominence
in pharmaceutical research, accounting for nearly 50% of all Food
and Drug Administration (FDA)-approved drugs. Notable examples include benzimidazole, benzothiazole, benzoxazole,
indole, quinazolinone, among others, as well as the various forms
of imidazopyridines. Imidazopyridines deserve special emphasis because they combine pyridine
and imidazole nuclei within a single fused system. These structures
may occur in several isomeric arrangements () and have been widely explored in the literature
because of their chemical and biological relevance. Imidazopyridine, with
emphasis on isomerism on the isomer that
will be discussed in this work, imidazo[1,2-]pyridine. The imidazo[1,2-]pyridine nucleus
is a fused
heterocyclic system (5,6-bicyclic ring) that has emerged as a privileged
scaffold in medicinal chemistry because of its substantial structural
versatility and broad spectrum of reported bioactivities. This versatility is reflected not only in research compounds but
also in clinically approved drugs, including sedatives and other therapeutic
agents based on the imidazo[1,2-]pyridine framework (). Moreover,
the fused heterocyclic architecture provides conformational rigidity,
an advantageous density of heteroatoms (particularly nitrogen atoms),
and flexibility for chemical modifications at multiple positions of
the ring. These features facilitate the exploration of specific molecular
interactions and optimization of key pharmacological properties, such
as affinity, selectivity, and pharmacokinetic behavior. Given the
global challenges posed by diseases such as cancer, infections, and
neurodegenerative disorders, as well as the ongoing need for therapies
with improved efficacy and safety profiles, versatile scaffolds such
as imidazo[1,2-]pyridine remain highly valuable
in contemporary drug discovery and development research.
scaffolds in the design of new bioactive
compounds in medicinal chemistry, owing to their structural diversity
and the fact that many of them participate in a wide range of biochemical
processes. Their significance arises from the extensive variability
in ring size, the number and nature of the heteroatoms, which may
include one or more, and the incorporation of diverse functional groups
in the ring structure. Altogether, these features make heterocyclic
chemistry particularly attractive. Among the most extensively investigated
heterocycles, nitrogen-containing systems have gained increasing prominence
in pharmaceutical research, accounting for nearly 50% of all Food
and Drug Administration (FDA)-approved drugs. Notable examples include benzimidazole, benzothiazole, benzoxazole,
indole, quinazolinone, among others, as well as the various forms
of imidazopyridines. Imidazopyridines deserve special emphasis because they combine pyridine
and imidazole nuclei within a single fused system. These structures
may occur in several isomeric arrangements () and have been widely explored in the literature
because of their chemical and biological relevance. Imidazopyridine, with
emphasis on isomerism on the isomer that
will be discussed in this work, imidazo[1,2-]pyridine. The imidazo[1,2-]pyridine nucleus
is a fused
heterocyclic system (5,6-bicyclic ring) that has emerged as a privileged
scaffold in medicinal chemistry because of its substantial structural
versatility and broad spectrum of reported bioactivities. This versatility is reflected not only in research compounds but
also in clinically approved drugs, including sedatives and other therapeutic
agents based on the imidazo[1,2-]pyridine framework (). Moreover,
the fused heterocyclic architecture provides conformational rigidity,
an advantageous density of heteroatoms (particularly nitrogen atoms),
and flexibility for chemical modifications at multiple positions of
the ring. These features facilitate the exploration of specific molecular
interactions and optimization of key pharmacological properties, such
as affinity, selectivity, and pharmacokinetic behavior. Given the
global challenges posed by diseases such as cancer, infections, and
neurodegenerative disorders, as well as the ongoing need for therapies
with improved efficacy and safety profiles, versatile scaffolds such
as imidazo[1,2-]pyridine remain highly valuable
in contemporary drug discovery and development research.