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Evidence-based recommendations for the use of continuous glucose monitoring in type 2 diabetes: the Italian guidelines.

Authors: Giaccari A, Gliozzo G, Ciccarelli G, Di Giuseppe G, Castellano C, Cum S, Delle Monache L, Gallo M, Lastretti M, Medea G, Monesi M, Napoli R, Pintaudi B, Succurro E, Turchetti G
Journal: Acta diabetologica
anxiety disorders mental health open access

Abstract

Approximately 50%–80% of individuals with stroke experience upper‐limb hemiparesis during the acute phase, and nearly 50% continue to have persistent paresis in the chronic phase (Nakayama et al. ; Lawrence et al. ; Persson et al. ). Persistent upper‐limb paresis limits activities of daily living and reduces quality of life. Therefore, improving upper‐limb function remains a major goal of stroke rehabilitation. Recovery of upper‐limb function after stroke is influenced by the intensity and amount of task‐specific practice received during rehabilitation. Experimental and clinical evidence suggests that increasing the intensity and repetition of task‐specific practice promotes experience‐dependent neural plasticity and motor recovery, making practice dosage a key component of stroke rehabilitation (Kleim and Jones ; Veerbeek et al. ). Accordingly, task‐oriented training (TOT), which involves repetitive practice of functional tasks, is widely recommended to improve upper‐limb function after stroke (Pollock et al. ; French et al. ). Upper‐limb task‐oriented training (UL‐TOT) builds on this principle by emphasizing intensive, high‐repetition practice to promote motor recovery. Previous studies have demonstrated that high‐repetition task‐oriented upper‐limb training is feasible in individuals with stroke, with approximately 300 repetitions performed within a one‐hour training session (Birkenmeier et al. ; Waddell et al. ; Lang et al. ). However, despite the feasibility of delivering high‐dose task‐oriented training, the practice dosage achieved varies considerably among individuals, posing a challenge to the delivery of high‐dose rehabilitation. Relatively little is known about the factors contributing to this variability during UL‐TOT. In the parent randomized controlled trial (RCT), participants with subacute stroke received Trunk Restraint Task‐Oriented Training (TR‐TOT). This therapeutic approach reduces compensatory anterior trunk displacement and facilitates effective use of the paretic upper‐limb during reaching task practice. Although the intervention targeted 300 repetitions within a one‐hour session, considerable variability in the practice dosage was observed across participants. Multiple factors may influence practice dosage during UL‐TOT, including participant‐related demographic and clinical characteristics such as age, sex, stroke type, lesion location and volume, poststroke duration, upper‐limb paresis severity, spasticity severity, and depression severity. Other participant‐, task‐, and contextual factors may also contribute to variability in practice dosage. However, the present exploratory secondary analysis was limited to the demographic and clinical variables available within the parent trial dataset.