Factors associated with persistent postoperative hyperthermia in pediatric craniocerebral injury: a retrospective cohort study and preliminary risk score.

Gestational diabetes mellitus (GDM) is a transient form of diabetes affecting 1 in 10 US pregnancies, and up to 25% of pregnancies globally [, ]. GDM confers more than sevenfold increased risk of developing type 2 diabetes mellitus with ∼10% women being diagnosed soon after delivery and 20%–60% of women being diagnosed within 5–10 years post‐index pregnancy []. Additionally, children born to mothers with GDM are at a higher risk to develop T2DM and obesity []. There are various risk factors for GDM, including high body‐mass index (BMI), higher maternal age, racial and ethnic group, and excessive weight gain during pregnancy []. There is also increasing evidence of GDM heterogeneity in both the timing of its diagnosis (early vs. late), and its underlying pathophysiology, for example, insulin resistance and/or insulin deficiency [, ]. Polygenic risk scores (PRS) have become a powerful tool providing insight into an individual's genetic predisposition for conditions based on aggregated genome‐wide association study results. PRS offers a modality to predict genetic disease risk burden in an effort to reduce associated morbidities through improved screening and earlier interventions. Currently, there are many GDM prediction and association studies, but there are very few that utilize PRS scores combined with clinical characteristics in pregnant individuals [, ]. Most GDM association publications focus on variables that are in electronic health records, such as age, weight, and body measurements. However, by integrating additional predictive characteristics, such as sociodemographics, behavioral, and biochemical factors, this could improve accuracy for a GDM risk prediction model, and help stratify individuals who may benefit from knowing their PRS to determine optimal intervention strategies []. The objective of this study was to look at clinical characteristics in PRS quartiles of individuals in the Hoosier Mom's Cohort (HMC), which preferentially recruited individuals with higher risk of development of GDM. We hypothesized that by better understanding characteristics within the PRS quartiles, we could more accurately identify individuals at risk for GDM eligible for early preventive interventions. Additionally, it will continue to expand research looking at clinical characteristics of pregnant individuals based on a genetic‐risk outcome.