Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice.

Ulcerative colitis‐associated neoplasia (UCAN), which includes both dysplasia and colitis‐associated colorectal carcinoma, remains a major complication of long‐standing ulcerative colitis [, ]. Endoscopic resection is recommended for visible dysplastic lesions when complete removal is feasible; however, accurate delineation of UCAN remains challenging because chronic inflammation, scarring, and mucosal distortion frequently obscure lesion borders []. Endoscopic submucosal dissection (ESD) enables organ‐preserving treatment of selected UCAN lesions but requires precise assessment of lesion extent before resection. Although image‐enhanced endoscopy, magnifying endoscopy, and chromoendoscopy have improved the detection and characterization of UCAN, delineation of lesion margins remains difficult in some cases. Therefore, additional techniques that complement conventional endoscopic evaluation may facilitate the determination of resection margins. We recently developed CV‐SCAN (crystal violet staining for colitis‐associated neoplasia), a novel staining method that identifies UCAN as CV‐neoplasia (CV‐N) areas []. Here, we report four patients in whom CV‐SCAN was used to delineate lesion extent before ESD and discuss its potential role as an adjunctive technique for endoscopic management of UCAN.