Development of Arginine Stearate-Based Solid Lipid Nanoparticles for Enhanced Idebenone Delivery: In Vitro Evaluation on Glioblastoma Model.

Acute coronary syndrome (ACS) is classically attributed to plaque rupture. However, plaque erosion is now recognized as an equally important mechanism, accounting for up to 40% of ACS cases. It is more common in women, younger patients, and smokers, and is associated with platelet-rich (“white”), often non-occlusive thrombi, more frequently leading to non-ST-elevation myocardial infarction (NSTEMI). High-resolution intravascular imaging, particularly optical coherence tomography (OCT), is considered the gold standard for differentiating these mechanisms. Type 2 diabetes mellitus (T2DM) remains a major cardiovascular risk factor, promoting endothelial dysfunction and increased platelet reactivity []. A 62-year-old woman with hypertension and newly diagnosed T2DM was admitted due to worsening exercise tolerance over 3 days and chest pain increasing in intensity over several hours. Electrocardiography showed ST-segment depression and T-wave inversion in leads III and aVF. Laboratory findings revealed a dynamic rise in troponin I (peak 139.68 ng/l), glycated hemoglobin of 8.3%, and non-high-density lipoprotein (HDL) cholesterol of 2.75 mmol/l. Urgent coronary angiography demonstrated significant stenosis of the right coronary artery with visible thrombotic material (). Aspiration thrombectomy was performed, retrieving macroscopic thrombus, followed by implantation of a drug-eluting stent (Xience Pro 3.5 × 24 mm). Adjunctive therapy included intracoronary eptifibatide and intravenous infusion. Angiographic results were satisfactory, with restored distal flow () and no procedural complications. The patient was discharged on dual antiplatelet therapy with acetylsalicylic acid and ticagrelor. Angiograms of the right coronary artery before and after percutaneous coronary intervention (PCI) and macroscopic appearance of the thrombus. – Angiogram showing significant stenosis of the right coronary artery with visible thrombotic material (sites of stenosis are indicated by arrows). – Macroscopically retrieved thrombus obtained by aspiration thrombectomy. – Final angiographic result after thrombectomy and drug-eluting stent implantation, demonstrating restored coronary flow