Chemical characterization of aconite polysaccharide and its ameliorative effect on ulcerative colitis by regulating gut microbiota and THDCA-driven TGR5/cAMP/PKA/NLRP3 pathway.

Atrial fibrillation (AF) is the most common tachyarrhythmia and significantly increases the risk of severe cardiovascular complications, such as stroke, myocardial infarction, and heart failure. AF is becoming a public health problem with a substantial financial burden (). Pregnancy is associated with physiological changes in the cardiovascular system, including structural and hemodynamic alterations, which might increase the risk of women suffering from AF. AF during pregnancy and puerperium can result in a high risk of embolic events and hemodynamic instability, and is devastating for maternal and fetal outcomes. Nevertheless, there are limited studies investigating the prevalence and outcomes in patients with AF during pregnancy and puerperium. The CHADS-VASc [C: congestive heart failure, H: hypertension, A: age of ≥75 years (doubled), D: diabetes mellitus, S: previous stroke (doubled), V: vascular disease, A: age between 65 and 74 years, Sc: female gender] scoring system is used in non-valvular AF patients to stratify the risk of thromboembolism and guide the anticoagulation strategy (). However, maternal patients were excluded from the CHADS-VASc application. Limited research has been conducted on using the value of the CHADS-VASc score in maternal patients. We aimed to fill the knowledge gaps by investigating the prevalence of AF during pregnancy and puerperium and its association with adverse outcomes. We also assessed the association between CHADS-VASc scores and adverse outcomes in maternal patients with AF.