2-(Arylamino)thiazol-4(5H)-ones Mitigate Oxidative Stress and Confer Neuroprotection in Cellular and Drosophila Models of Alzheimer's Disease.

Healthcare delivery systems are complex sociotechnical environments in which people, processes, technologies, and organizational structures interact to shape care delivery. Human factors science emphasizes that safe, effective, and patient-centered care emerges from work systems designed to align with human capabilities and limitations rather than relying on individual vigilance alone [,]. The Systems Engineering Initiative for Patient Safety (SEIPS) 2.0 framework provides a structured approach to understanding this complexity. In this model, a sociotechnical work system composed of persons, tasks, tools and technologies, organizational conditions, and environments gives rise to care processes that shape patient, professional, and organizational outcomes []. Outcomes therefore emerge from interactions among system components rather than from isolated actions. This systems perspective also applies to organizational culture. Culture is shaped by the structures, workflows, and incentives that govern daily work. As a result, efforts to improve culture without redesigning underlying systems frequently fail to produce sustained change []. Reliability similarly emerges from systems that support consistent performance under varying clinical conditions and is best understood as a property of the system rather than of individual clinicians [,].