Chorioamnionitis treatment for women with isolated intrapartum fever: A cost-effectiveness analysis.

Preeclampsia (PE) is a life‐threatening condition that can cause severe neonatal and maternal complications if not treated promptly. It is considered a major cause of maternal and neonatal death worldwide, an estimated 4 million people are diagnosed with PE each year, leading to the deaths of more than 70,000 people and over 500,000 infants []. Neurodegenerative disorders, particularly dementia, often lead to significant disability, placing a substantial financial burden on society due to the high costs of treatment and long‐term care. A study examining a subpopulation from the Health and Retirement Study found that the financial burden of dementia is comparable to that of heart disease and cancer []. Given that neurodegenerative diseases contribute to a high number of disability‐adjusted life years, they are a major driver of global health burden. Twice as many women as men are affected by Alzheimer's disease, a disparity that may be explained by genetic risk factors, such as the presence of the APOE4 lipoprotein mutation, which can affect men and women equally; however, women who carry this mutation are more likely to develop mild cognitive impairment []. Women generally have higher levels of tau protein, a biomarker for Alzheimer's, in their brains compared to men. A study recently found that women with high β‐amyloid (Aβ) levels exhibited significantly faster tau accumulation than men with similar Aβ levels. Additionally, female carriers of the APOEε4 allele showed faster tau accumulation in the inferior temporal region compared to male carriers. These findings suggest that women may be at greater risk for Alzheimer's disease progression due to more aggressive tau pathology in the presence of Aβ []. Depression is another factor to consider, as it also contributes to an increased risk of Alzheimer's disease. Women are twice as likely to experience depression as men []. While prospective studies have identified an association between PE and dementia, as well as anatomical changes in the occipital region of the brain and cognitive impairment, retrospective studies have contradicted these findings, reporting no association between PE and Alzheimer's disease [, ]. Exploring the relationship between PE and neurodegenerative disorders is crucial for improving diagnostics, reducing costs, optimizing resource allocation, and alleviating public health burden. This report examines whether PE is associated with increased risk of dementia, Parkinson's disease, and cognitive impairment later in life with a robust sample size and follow‐up time. We hypothesize that PE increases the risk of these neurodegenerative diseases.